Molecules

Tetrofosmin

Target Myocardial perfusionClass Lipophilic cationic technetium complex (diphosphine)

0ongoing trials
1radiolabelled forms
1approved products
1,633publications (PubMed)

Structure

Structure from the cited PubChem record (unlabelled ligand, or the labelled form when PubChem only describes that one). Conformer: RDKit (computed conformer, indicative). Rotate with the mouse or a finger.

Properties (PubChem)

Molecular formula
C18H40O4P2
Molar mass (g/mol)
382.5
Exact mass (Da)
382.2402
XLogP
0.5
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
19
Heavy atoms
24
InChIKey
QCWJONLQSHEGEJ-UHFFFAOYSA-N
PubChem record
CID 4274 ↗
IUPAC name
2-[bis(2-ethoxyethyl)phosphanyl]ethyl-bis(2-ethoxyethyl)phosphane
SMILES
CCOCCP(CCOCC)CCP(CCOCC)CCOCC

Radiolabelled forms

FormUseMolar mass (labelled form)Ongoing trialsMost advanced phaseApproval
[⁹⁹ᵐTc]Tc-tetrofosmin Syntheses and QC ↗Imaging899.80—SPECT perfusion (sestamibi, tetrofosmin, thallium) US EU FR JP
Other trials listing it among the interventions (comparator, associated scan) · 1
Dyna-MI · Myocardial perfusion tracersNCT05940285 · Ischemic heart diseaseNo phaseActive, not recruitingNantes University Hospital1

PublicationsAll publications in PubMed ↗

1,633 publications in PubMed for the query below; the most recent:

tetrofosmin[tiab]

  1. Comparative diagnostic performance of [(18)F] flurpiridaz PET and SPECT myocardial perfusion imaging (MPI): a systematic review and meta-analysis Eur J Nucl Med Mol Imaging, 2026
  2. Pancreatic Uptake on 99m Tc-MIBI and 99m Tc-Tetrofosmin Myocardial Perfusion SPECT/CT Clin Nucl Med, 2026
  3. Long-term Prognostic Value of Stress Phase Entropy for Predicting Major Cardiac Events in Patients with Known or Suspected Coronary Artery Disease Intern Med, 2026
  4. Recent Progress in PET and SPECT Myocardial Perfusion Imaging: From Radiopharmaceuticals to Imaging Innovations Iran J Pharm Res, 2026
  5. Quantitative and semi-quantitative comparison of myocardial blood flow between (99m)Tc-tetrofosmin and (99m)Tc-sestamibi: based on continuous rapid dynamic imaging technology using cadmium-zinc-telluride cardiac single-photon emission computed tomography Quant Imaging Med Surg, 2026
  6. Challenges in Cardiac Risk Stratification for Bariatric Surgery: A Single-Centre Experience Obes Surg, 2026
  7. Correction: Quality and pratical determinants in [(99m)Tc]Tc-tetrofosmin preparation: hygrometry, syringe sorption & maximal activity per kit EJNMMI Radiopharm Chem, 2026
  8. Platform-specific impact of CT attenuation correction on CZT myocardial perfusion SPECT: per-vessel detection of obstructive coronary artery disease Int J Cardiovasc Imaging, 2026

Sources: PubChem and PubMed (NCBI), ClinicalTrials.gov and CTIS registries, approvals recorded by the atlas. PubChem data as of 28 October 2026.

Cite this page

Tetrofosmin. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 27 October 2026. https://theranosticatlas.com/molecule/tetrofosmin/ (accessed [date]).

A monitoring tool with no regulatory value: check every item at its source.