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Ioflupane Target Neurotransmission (receptors, enzymes) Class Tropane (cocaine analogue) Other names FP-CIT
1 ongoing trials
2 radiolabelled forms
1 approved products
1,820 publications (PubMed)
Structure 3D 2D
Structure from the cited PubChem record (unlabelled ligand, or the labelled form when PubChem only describes that one). Conformer: PubChem (3D conformer computed by PubChem). Rotate with the mouse or a finger.
Properties (PubChem) Molecular formula C18H23FINO2 Molar mass (g/mol) 431.3 Exact mass (Da) 431.0758 XLogP 4 H-bond donors 0 H-bond acceptors 4 Rotatable bonds 6 Heavy atoms 23 InChIKey HXWLAJVUJSVENX-HZMVEIRTSA-N PubChem record CID 10048368 ↗ IUPAC name methyl (1R,2S,3S,5S)-8-(3-fluoropropyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate SMILES COC(=O)[C@@H]1[C@H]2CC[C@H](N2CCCF)C[C@@H]1C3=CC=C(C=C3)I Radiolabelled forms Form Use Molar mass (labelled form) Ongoing trials Most advanced phase Approval [¹²³I]ioflupane Syntheses and QC ↗ Imaging 427.3 1 No phase DaTscan US EU FR JP [¹⁸F]FP-CIT Syntheses and QC ↗ Imaging — 0 — —
Atlas trials whose studied drug or title names this vector, with this radionuclide.
Trial Phase Status Sponsor Countries Dopamine transporter tracers NCT01453127 · Alzheimer's disease and cognitive disorders No phase By invitation Mayo Clinic 1
Other trials listing it among the interventions (comparator, associated scan) · 1 NUK-RBD · [18F]FDG NCT06629207 · Alzheimer's disease and cognitive disorders No phase Recruiting Insel Gruppe AG, University Hospital Bern 1
1,820 publications in PubMed for the query below; the most recent:
ioflupane[tiab] OR FP-CIT[tiab] OR DaTscan[tiab]
Clinical utility of DaTscan in clinically uncertain parkinsonian syndromes: a systematic review and meta‑analysis J Clin Neurosci, 2026 Disproportionately Enlarged Subarachnoid Space Hydrocephalus (DESH) Identified on I-123 Ioflupane SPECT/CT Clin Nucl Med, 2026 REM sleep without atonia thresholds are associated with reduced cardiac MIBG uptake but not with DAT-SPECT binding in probable REM sleep behavior Sleep Med, 2026 Striatal DAT-SPECT texture beyond mean binding in major depressive disorder J Affect Disord, 2026 DAT-SPECT findings in POLR3A-related striatal variant: a case report and literature review Parkinsonism Relat Disord, 2026 Baseline Wearable Turning-Derived Signature and Dopamine Transporter-Derived Measures in Relation to Subsequent Motor Progression in Parkinson's Disease: An Exploratory Longitudinal Study Sensors (Basel), 2026 Hierarchical deep learning-radiomics fusion for differentiating Parkinson's disease from atypical Parkinsonism using FP-CIT imaging Parkinsonism Relat Disord, 2026 Evaluation of Optimal Ordered Subset Expectation Maximization Reconstruction for [I-123]FP-CIT Single-Photon Emission Computed Tomography Using a Ring-Type Semiconductor Scanner Tohoku J Exp Med, 2026 Sources: PubChem and PubMed (NCBI), ClinicalTrials.gov and CTIS registries, approvals recorded by the atlas. PubChem data as of 28 October 2026.
Cite this page Ioflupane. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 27 October 2026. https://theranosticatlas.com/molecule/ioflupane/ (accessed [date]).
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