Neurotransmission (receptors, enzymes)

Ongoing clinical trials and approved products targeting Neurotransmission (receptors, enzymes), in radioligand therapy and PET/SPECT imaging. Data as of 26 October 2026.

0ongoing therapy trials
33ongoing imaging trials
0approved products

Target note

Full name
Receptors, transporters and enzymes of neurotransmission
Nature
A set of high-affinity radioligands for brain targets: dopaminergic, serotonergic, glutamatergic, opioid, cannabinoid and cholinergic receptors, enzymes (MAO-B, PDE, HDAC).
Normal expression
A distribution specific to each target in the healthy brain, used as a reference.
Value
Research tools to understand psychiatric and neurological diseases and to measure target occupancy by drugs (drug development).
Approaches
Examples: [11C]raclopride (D2/D3), [18F]FEOBV (vesicular acetylcholine transporter), [11C]Cimbi-36 (5-HT2A), [18F]FPEB (mGluR5), [11C]carfentanil (opioids).
Indications explored
Psychiatry, addiction, Parkinson's disease, epilepsy, drug occupancy studies.
Points of caution
Mostly labeled with ¹¹C, so limited to centres with a cyclotron; quantification by kinetic modelling, sometimes with arterial sampling.

Ongoing imaging trials · 33Open in the radar →

TrialPhaseStatusSponsorCountries
Brain receptors, transporters and enzymes2024-516610-38-00 · Parkinson's disease and parkinsonian syndromesPhase 3Not yet recruitingInstitut National De La Sante Et De La Recherche Medicale1
Brain receptors, transporters and enzymesNCT07265596 · Parkinson's disease and parkinsonian syndromesPhase 2RecruitingMichael J. Fox Foundation for Parkinson's Research6
Brain receptors, transporters and enzymesNCT07830654 · Parkinson's disease and parkinsonian syndromesPhase 2RecruitingMichael J. Fox Foundation for Parkinson's Research1
Brain receptors, transporters and enzymesNCT05231798 · Alzheimer's disease and cognitive disordersPhase 2RecruitingVanderbilt University Medical Center1
[18F]fluortriopride (D3)NCT02815917 · Psychiatry and addictionPhase 2Active, not recruitingUniversity of Pennsylvania1
Brain receptors, transporters and enzymesNCT07809438 · Parkinson's disease and parkinsonian syndromesPhase 2RecruitingMichael J. Fox Foundation for Parkinson's Research1
Brain receptors, transporters and enzymesNCT07559500 · Psychiatry and addictionPhase 1RecruitingNational Institute on Alcohol Abuse and Alcoholism (NIAAA)1
Brain receptors, transporters and enzymesNCT06599151 · OtherPhase 1Not yet recruitingStanford University0
Brain receptors, transporters and enzymesNCT05703685 · Psychiatry and addictionPhase 1RecruitingNational Institute of Mental Health (NIMH)1
Brain receptors, transporters and enzymesNCT04401917 · Psychiatry and addictionPhase 1Active, not recruitingUniversity of Pennsylvania1
Brain receptors, transporters and enzymesNCT06874205 · Healthy volunteers (dosimetry, biodistribution)Phase 1RecruitingNational Institute of Mental Health (NIMH)1
MISDEP · Brain receptors, transporters and enzymesNCT06977308 · OtherPhase 1Not yet recruitingNew York State Psychiatric Institute0
Brain receptors, transporters and enzymesNCT07470710 · Other neurodegenerative diseasesPhase 1Not yet recruitingPeking Union Medical College Hospital0
Brain receptors, transporters and enzymesNCT07625345 · Healthy volunteers (dosimetry, biodistribution)Phase 1RecruitingNational Institute of Mental Health (NIMH)1
Brain receptors, transporters and enzymesNCT07853781 · Healthy volunteers (dosimetry, biodistribution)Phase 1RecruitingNational Institute of Mental Health (NIMH)1
ISO-1Primary · Brain receptors, transporters and enzymesNCT02284919 · BreastPhase 1Active, not recruitingUniversity of Pennsylvania1
Brain receptors, transporters and enzymesNCT06795581 · Psychiatry and addictionPhase 1RecruitingNational Institute of Mental Health (NIMH)1
Brain receptors, transporters and enzymesNCT07027839 · Psychiatry and addictionPhase 1RecruitingNational Institute of Mental Health (NIMH)1
Brain receptors, transporters and enzymesNCT07457736 · Healthy volunteers (dosimetry, biodistribution)Phase 1RecruitingYale University1
Brain receptors, transporters and enzymesNCT07612631 · Psychiatry and addictionPhase 1RecruitingRajesh Narendran1
Brain receptors, transporters and enzymesNCT07800520 · Psychiatry and addictionPhase 1RecruitingYale University1
Brain receptors, transporters and enzymesNCT05008146 · Psychiatry and addictionPhase 1RecruitingRajesh Narendran1
Brain receptors, transporters and enzymesNCT05683184 · Psychiatry and addictionPhase 1RecruitingYale University1
Brain receptors, transporters and enzymesNCT05528848 · Psychiatry and addictionPhase 1Active, not recruitingUniversity of Pennsylvania1
Brain receptors, transporters and enzymesNCT03442413 · Psychiatry and addictionPhase 1Active, not recruitingUniversity of Pennsylvania1
FenDep · Brain receptors, transporters and enzymesNCT07651293 · Psychiatry and addictionNo phaseNot yet recruitingImperial College Healthcare NHS Trust1
F-DED PET MS · Brain receptors, transporters and enzymesNCT07805473 · Neuroinflammation and multiple sclerosisNo phaseNot yet recruitingParc de Salut Mar1
Brain receptors, transporters and enzymesNCT03549559 · Heart failure and cardiomyopathiesNo phaseRecruitingMassachusetts General Hospital1
Brain receptors, transporters and enzymesNCT05357612 · Parkinson's disease and parkinsonian syndromesNo phaseRecruitingVanderbilt University Medical Center1
PAINPARK · Brain receptors, transporters and enzymesNCT07127146 · Parkinson's disease and parkinsonian syndromesNo phaseNot yet recruitingHospices Civils de Lyon1
PD-Pain · Brain receptors, transporters and enzymesNCT06008704 · Parkinson's disease and parkinsonian syndromesNo phaseRecruitingUniversity Hospital, Toulouse1
DRAPETONINE · Brain receptors, transporters and enzymesNCT07013331 · EpilepsyNo phaseRecruitingHospices Civils de Lyon1
CB1R in Spice · Brain receptors, transporters and enzymesNCT03539575 · OtherNo phaseActive, not recruitingYale University1

Cite this page

Neurotransmission (receptors, enzymes). Theranostic Atlas, LaRadiopharmacie.fr. Data as of 26 October 2026. https://theranosticatlas.com/target/neurotransmission-receptors-enzymes/ (accessed [date]).

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