Molecules

Iobenguane (MIBG)

Target Norepinephrine transporterClass Norepinephrine analogueOther names meta-iodobenzylguanidine

7ongoing trials
2radiolabelled forms
3approved products
5,542publications (PubMed)

Structure

Structure from the cited PubChem record (unlabelled ligand, or the labelled form when PubChem only describes that one). Conformer: PubChem (3D conformer computed by PubChem). Rotate with the mouse or a finger.

Properties (PubChem)

Molecular formula
C8H10IN3
Molar mass (g/mol)
275.09
Exact mass (Da)
274.9919
XLogP
1
H-bond donors
2
H-bond acceptors
1
Rotatable bonds
2
Heavy atoms
12
InChIKey
PDWUPXJEEYOOTR-UHFFFAOYSA-N
PubChem record
CID 60860 ↗
IUPAC name
2-[(3-iodophenyl)methyl]guanidine
SMILES
C1=CC(=CC(=C1)I)CN=C(N)N

Radiolabelled forms

FormUseMolar mass (labelled form)Ongoing trialsMost advanced phaseApproval
[¹²³I]MIBG Syntheses and QC ↗Imaging271.092Phase 1MIBG [123I] (AdreView…) US EU FR JP
[¹³¹I]MIBG Syntheses and QC ↗Therapy279.095Phase 3MIBG [131I] for therapy EU FR JP, Azedra

Ongoing trials · 7Open in the radar →

Atlas trials whose studied drug or title names this vector, with this radionuclide.

TrialPhaseStatusSponsorCountries
[131I]MIBGNCT03126916 · NeuroblastomaPhase 3RecruitingChildren's Oncology Group3
[131I]MIBGNCT07261241 · NeuroblastomaPhase 2Not yet recruitingNew Approaches to Neuroblastoma Therapy Consortium1
MIBG · [131I]MIBGNCT02378428 · Solid tumors (multiple indications)Phase 2Active, not recruitingNationwide Children's Hospital1
[131I]MIBGNCT00107289 · NeuroblastomaPhase 2RecruitingMemorial Sloan Kettering Cancer Center1
MIBG and analogues (innervation, neural crest)2024-513310-36-01 · Cardiac amyloidosisPhase 1Not yet recruitingUniversitair Medisch Centrum Groningen1
MiniVan · [131I]MIBGNCT02914405 · NeuroblastomaPhase 1Active, not recruitingUniversity Hospital Southampton NHS Foundation Trust2
MIBG and analogues (innervation, neural crest)NCT05514106 · Alzheimer's disease and cognitive disordersNo phaseBy invitationMayo Clinic1
Other trials listing it among the interventions (comparator, associated scan) · 1
[177Lu]Lu-edotreotide (ITM-11)NCT03044977 · Gastroenteropancreatic NETsPhase 1Active, not recruitingDavid Bushnell1

PublicationsAll publications in PubMed ↗

5,542 publications in PubMed for the query below; the most recent:

MIBG[tiab] OR iobenguane[tiab] OR metaiodobenzylguanidine[tiab]

  1. Escherichia coli hns and methylglyoxal link gut microbial metabolism to host neuronal gene regulation in Parkinson's disease Gut Microbes, 2026
  2. Unilateral mixed corticomedullary tumor of the adrenal gland with a synchronous contralateral pheochromocytoma: A case report and literature review Urol Case Rep, 2026
  3. A case of metastasectomy following multiple courses of radionuclide therapy for distant metastatic pheochromocytoma JCEM Case Rep, 2026
  4. False-Positive 123I-MIBG Uptake Attributable to Contralateral Erector Spinae Muscle Hypertrophy Following Retroperitoneal Surgery in a Child With Neuroblastoma Clin Nucl Med, 2026
  5. REM sleep without atonia thresholds are associated with reduced cardiac MIBG uptake but not with DAT-SPECT binding in probable REM sleep behavior Sleep Med, 2026
  6. [A case of Parkinsonism possibly associated with long-term methamphetamine use] Rinsho Shinkeigaku, 2026
  7. Unusual Isolated Thymic Relapse of Neuroblastoma Detected By 123I-mIBG Scintigraphy in a Pediatric Patient Clin Nucl Med, 2026
  8. Impact of (131)I-MIBG dose escalation (12 vs. 18 mCi/kg) during conditioning for autologous hematopoietic stem cell transplantation in pediatric neuroblastoma: a retrospective cohort study Eur J Pediatr, 2026

Sources: PubChem and PubMed (NCBI), ClinicalTrials.gov and CTIS registries, approvals recorded by the atlas. PubChem data as of 28 October 2026.

Cite this page

Iobenguane (MIBG). Theranostic Atlas, LaRadiopharmacie.fr. Data as of 27 October 2026. https://theranosticatlas.com/molecule/iobenguane/ (accessed [date]).

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