Molecules

Fluoromisonidazole

Target HypoxiaClass NitroimidazoleOther names FMISO

12ongoing trials
1radiolabelled forms
0approved products
686publications (PubMed)

Structure

Structure from the cited PubChem record (unlabelled ligand, or the labelled form when PubChem only describes that one). Conformer: PubChem (3D conformer computed by PubChem). Rotate with the mouse or a finger.

Properties (PubChem)

Molecular formula
C6H8FN3O3
Molar mass (g/mol)
189.14
Exact mass (Da)
189.055
XLogP
-0.5
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
13
InChIKey
HIIJZYSUEJYLMX-UHFFFAOYSA-N
PubChem record
CID 92242 ↗
IUPAC name
1-fluoro-3-(2-nitroimidazol-1-yl)propan-2-ol
SMILES
C1=CN(C(=N1)[N+](=O)[O-])CC(CF)O

Radiolabelled forms

FormUseMolar mass (labelled form)Ongoing trialsMost advanced phaseApproval
[¹⁸F]FMISO Syntheses and QC ↗Imaging188.1512Phase 2—

Ongoing trials · 12Open in the radar →

Atlas trials whose studied drug or title names this vector, with this radionuclide.

TrialPhaseStatusSponsorCountries
Hypoxia tracers (FMISO, FAZA, ATSM)NCT03649880 · Brain (glioma, medulloblastoma…)Phase 2RecruitingOHSU Knight Cancer Institute1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT03168737 · BreastPhase 1Active, not recruitingM.D. Anderson Cancer Center1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT04332588 · BreastPhase 1RecruitingUniversity of Alabama at Birmingham1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT04861077 · BreastPhase 1RecruitingUniversity of Alabama at Birmingham1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT05047913 · Brain (glioma, medulloblastoma…)Phase 1Active, not recruitingM.D. Anderson Cancer Center1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT07778979 · Brain (glioma, medulloblastoma…)Phase 1Not yet recruitingUniversity of Alabama at Birmingham1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT05996432 · Head and neckPhase 1RecruitingVanderbilt-Ingram Cancer Center1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT03418818 · Sarcoma / boneNo phaseActive, not recruitingUniversity Health Network, Toronto1
FAZA Lung · Hypoxia tracers (FMISO, FAZA, ATSM)NCT02701699 · Non-small-cell lung cancerNo phaseActive, not recruitingUniversity Health Network, Toronto1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT04054609 · Ischemic heart diseaseNo phaseRecruitingUniversity Health Network, Toronto1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT01549730 · GynecologicalNo phaseActive, not recruitingUniversity Health Network, Toronto1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT04395469 · Pancreas (adenocarcinoma)No phaseActive, not recruitingUniversity Health Network, Toronto1

PublicationsAll publications in PubMed ↗

686 publications in PubMed for the query below; the most recent:

FMISO[tiab] OR fluoromisonidazole[tiab]

  1. Combined PET imaging of tumor hypoxia and proliferation in Glioblastoma using a single injection of 18F-FMISO and 18F-FLT: Association with sites of subsequent recurrence Med Phys, 2026
  2. Mild, Fast, and General Biocatalytic Deprotection Strategies for Automated Fluorine-18 Positron Emission Tomography Radiotracer Synthesis J Org Chem, 2026
  3. Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized (13)C MRI and PET Adv Sci (Weinh), 2026
  4. Prospective exploratory pilot study of 18 F-FMISO PET/CT for assessing tumor hypoxia in soft tissue sarcomas Cancer Imaging, 2026
  5. Diagnostic and Prognostic Value of Hypoxia PET in Glioma: A Systematic Review and Meta-Analysis Cancers (Basel), 2026
  6. Automated class-solution planning for biologically guided radiotherapy: a comparison with manual planning in head and neck cancer Phys Med, 2026
  7. Early FMISO PET changes as exploratory predictors of immune checkpoint inhibitor response in advanced lung cancer: a pilot study Sci Rep, 2026
  8. Utility of various positron emission tomography tracers in differentiating primary central nervous system lymphoma from glioblastoma multiforme EJNMMI Rep, 2026

Sources: PubChem and PubMed (NCBI), ClinicalTrials.gov and CTIS registries, approvals recorded by the atlas. PubChem data as of 28 October 2026.

Cite this page

Fluoromisonidazole. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 27 October 2026. https://theranosticatlas.com/molecule/fmiso/ (accessed [date]).

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