Hypoxia

Ongoing clinical trials and approved products targeting Hypoxia, in radioligand therapy and PET/SPECT imaging. Data as of 26 October 2026.

0ongoing therapy trials

12ongoing imaging trials

0approved products

Target note

Full name: Tumor hypoxia
Nature: Nitroimidazoles are reduced and trapped in hypoxic cells; Cu-ATSM is retained in a reducing environment.
Normal expression: Liver, bowel, urinary tract.
Value: Locating radioresistant areas to adapt the radiotherapy dose and select treatments targeting hypoxia.
Approaches: [18F]FMISO, [18F]FAZA, [18F]HX4, [64Cu]Cu-ATSM.
Indications explored: Head and neck and lung cancers, gliomas, cervical cancer.
Points of caution: Modest tumor contrast and late acquisitions.

Ongoing imaging trials · 12Open in the radar →

Trial	Phase	Status	Sponsor	Countries
Hypoxia tracers (FMISO, FAZA, ATSM)NCT03649880 · Brain (glioma, medulloblastoma…)	Phase 2	Recruiting	OHSU Knight Cancer Institute	1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT03168737 · Breast	Phase 1	Active, not recruiting	M.D. Anderson Cancer Center	1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT04332588 · Breast	Phase 1	Recruiting	University of Alabama at Birmingham	1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT04861077 · Breast	Phase 1	Recruiting	University of Alabama at Birmingham	1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT05047913 · Brain (glioma, medulloblastoma…)	Phase 1	Active, not recruiting	M.D. Anderson Cancer Center	1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT07778979 · Brain (glioma, medulloblastoma…)	Phase 1	Not yet recruiting	University of Alabama at Birmingham	1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT05996432 · Head and neck	Phase 1	Recruiting	Vanderbilt-Ingram Cancer Center	1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT03418818 · Sarcoma / bone	No phase	Active, not recruiting	University Health Network, Toronto	1
FAZA Lung · Hypoxia tracers (FMISO, FAZA, ATSM)NCT02701699 · Non-small-cell lung cancer	No phase	Active, not recruiting	University Health Network, Toronto	1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT04054609 · Ischemic heart disease	No phase	Recruiting	University Health Network, Toronto	1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT01549730 · Gynecological	No phase	Active, not recruiting	University Health Network, Toronto	1
Hypoxia tracers (FMISO, FAZA, ATSM)NCT04395469 · Pancreas (adenocarcinoma)	No phase	Active, not recruiting	University Health Network, Toronto	1

Cite this page

Hypoxia. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 26 October 2026. https://theranosticatlas.com/target/hypoxia/ (accessed [date]).

A monitoring tool with no regulatory value: check every item at its source.