Molecules

Fluorocholine

Target Choline (membrane metabolism)Class Choline analogueOther names fluoromethylcholine, FCH

11ongoing trials
2radiolabelled forms
1approved products
1,535publications (PubMed)

Structure

Structure from the cited PubChem record (unlabelled ligand, or the labelled form when PubChem only describes that one). Conformer: PubChem (3D conformer computed by PubChem). Rotate with the mouse or a finger.

Properties (PubChem)

Molecular formula
C5H13FNO+
Molar mass (g/mol)
122.16
Exact mass (Da)
122.0981
XLogP
0
H-bond donors
1
H-bond acceptors
2
Rotatable bonds
3
Heavy atoms
8
InChIKey
PBVFROWIWWGIFK-UHFFFAOYSA-N
PubChem record
CID 404592 ↗
IUPAC name
fluoromethyl-(2-hydroxyethyl)-dimethylazanium
SMILES
C[N+](C)(CCO)CF

Radiolabelled forms

FormUseMolar mass (labelled form)Ongoing trialsMost advanced phaseApproval
[¹⁸F]fluorocholine Syntheses and QC ↗Imaging121.1611Phase 3Choline ([11C] Mayo, [18F] IASOcholine…) US EU FR
[¹¹C]choline Syntheses and QC ↗Imaging103.170—Choline ([11C] Mayo, [18F] IASOcholine…) US EU FR

Ongoing trials · 11Open in the radar →

Atlas trials whose studied drug or title names this vector, with this radionuclide.

TrialPhaseStatusSponsorCountries
Labeled choline ([18F]/[11C])2025-520861-29-00 · Prostate – otherPhase 3Not yet recruitingA.C.O.M. Advanced Center Oncology Macerata S.r.l.1
Labeled choline ([18F]/[11C])NCT04150458 · OtherPhase 3By invitationSir Mortimer B. Davis - Jewish General Hospital1
F-choline · Labeled choline ([18F]/[11C])NCT04999215 · OtherPhase 3RecruitingCentre hospitalier de l'Université de Montréal (CHUM)1
Labeled choline ([18F]/[11C])NCT07444723 · HyperparathyroidismPhase 3RecruitingNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1
ADACHOL · Brain receptors, transporters and enzymesNCT03998852 · OtherPhase 3RecruitingUniversity Hospital, Bordeaux1
Brain receptors, transporters and enzymesNCT05231798 · Alzheimer's disease and cognitive disordersPhase 2RecruitingVanderbilt University Medical Center1
ExTRACT-HCC · Labeled choline ([18F]/[11C])NCT04965454 · Liver (HCC)Phase 2RecruitingQueen's Medical Center1
Labeled choline ([18F]/[11C])NCT07138820 · HyperparathyroidismNo phaseRecruitingRegion Skane1
Labeled choline ([18F]/[11C])NCT05359939 · Liver (HCC)No phaseRecruitingUniversity of Aarhus1
OPERANDI-HCC · Labeled choline ([18F]/[11C])NCT06334965 · Liver (HCC)No phaseRecruitingAssistance Publique - Hôpitaux de Paris1
MIM · [18F]FDGNCT04349358 · MyelomaNo phaseRecruitingCentre Georges Francois Leclerc1
Other trials listing it among the interventions (comparator, associated scan) · 1
[68Ga]Ga-DOTA-TATE/TOC/NOC2024-519505-35-00 · Gastroenteropancreatic NETsPhase 3RecruitingCentre Hospitalier Universitaire De Nantes1

PublicationsAll publications in PubMed ↗

1,535 publications in PubMed for the query below; the most recent:

fluorocholine[tiab] OR fluoromethylcholine[tiab] OR "choline PET"[tiab]

  1. Assessing the effectiveness of (18)F-Fluorocholine PET-CT as the leading imaging technique compared to (99m)Tc-Sestamibi scans and ultrasonography for diagnosing hyperparathyroidism Appl Radiat Isot, 2026
  2. Salvage high-dose-rate brachytherapy for isolated seminal vesicle recurrence following definitive treatment for prostate cancer Brachytherapy, 2026
  3. Whole-body MRI with DWIBS and choline PET/CT for detecting oligoprogressive castration-resistant prostate cancer recurrence Fukushima J Med Sci, 2026
  4. Parathyroid carcinoma: from molecular pathogenesis to multidisciplinary management J Clin Endocrinol Metab, 2026
  5. Value of Dual-Time-Point [(18)F]Fluorocholine PET/CT for Challenging Preoperative Parathyroid Imaging J Nucl Med, 2026
  6. Preoperative parathyroid imaging in CKD-related secondary hyperparathyroidism: a systematic review and diagnostic test accuracy network meta-analysis Clin Kidney J, 2026
  7. Preoperative ultrasound detection of arteria lusoria and non-recurrent laryngeal nerve anatomical variation: a retrospective study Ultraschall Med, 2026
  8. The Diagnostic Accuracy of [(18)F]Fluorocholine PET/CT for the Preoperative Localization of Hyperfunctioning Parathyroid Glands Diagnostics (Basel), 2026

Sources: PubChem and PubMed (NCBI), ClinicalTrials.gov and CTIS registries, approvals recorded by the atlas. PubChem data as of 28 October 2026.

Cite this page

Fluorocholine. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 27 October 2026. https://theranosticatlas.com/molecule/fluorocholine/ (accessed [date]).

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