Choline (membrane metabolism)

Ongoing clinical trials and approved products targeting Choline (membrane metabolism), in radioligand therapy and PET/SPECT imaging. Data as of 26 October 2026.

0ongoing therapy trials

8ongoing imaging trials

1approved products

Target note

Full name: Choline metabolism (membrane phospholipids)
Nature: Choline is phosphorylated by choline kinase, overexpressed in proliferating cells, and then incorporated into membranes.
Normal expression: Liver, pancreas, kidneys, salivary glands, bowel.
Value: Historical imaging of recurrent prostate cancer, now superseded by PSMA; an emerging reference for localising parathyroid adenomas.
Approaches: [18F]fluorocholine, [11C]choline.
Indications explored: Recurrent prostate cancer, well-differentiated hepatocellular carcinoma, primary hyperparathyroidism.
Points of caution: Inflammatory lymph node uptake; low sensitivity at low PSA.

Approved products

Choline ([11C] Mayo, [18F] IASOcholine…)[11C]choline, [18F]fluorocholine

Multiples

marketed

US EU FR

Ongoing imaging trials · 8Open in the radar →

Trial	Phase	Status	Sponsor	Countries
Labeled choline ([18F]/[11C])2025-520861-29-00 · Prostate – other	Phase 3	Not yet recruiting	A.C.O.M. Advanced Center Oncology Macerata S.r.l.	1
Labeled choline ([18F]/[11C])NCT04150458 · Other	Phase 3	By invitation	Sir Mortimer B. Davis - Jewish General Hospital	1
F-choline · Labeled choline ([18F]/[11C])NCT04999215 · Other	Phase 3	Recruiting	Centre hospitalier de l'Université de Montréal (CHUM)	1
Labeled choline ([18F]/[11C])NCT07444723 · Hyperparathyroidism	Phase 3	Recruiting	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	1
ExTRACT-HCC · Labeled choline ([18F]/[11C])NCT04965454 · Liver (HCC)	Phase 2	Recruiting	Queen's Medical Center	1
Labeled choline ([18F]/[11C])NCT07138820 · Hyperparathyroidism	No phase	Recruiting	Region Skane	1
Labeled choline ([18F]/[11C])NCT05359939 · Liver (HCC)	No phase	Recruiting	University of Aarhus	1
OPERANDI-HCC · Labeled choline ([18F]/[11C])NCT06334965 · Liver (HCC)	No phase	Recruiting	Assistance Publique - Hôpitaux de Paris	1

Cite this page

Choline (membrane metabolism). Theranostic Atlas, LaRadiopharmacie.fr. Data as of 26 October 2026. https://theranosticatlas.com/target/choline-membrane-metabolism/ (accessed [date]).

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