Sodium fluoride

Target Bone remodellingClass Fluoride ionOther names NaF

5ongoing trials

1radiolabelled forms

1approved products

708publications (PubMed)

Structure

Structure from the cited PubChem record (unlabelled ligand, or the labelled form when PubChem only describes that one). Conformer: RDKit (computed conformer, indicative). Rotate with the mouse or a finger.

Properties (PubChem)

Molecular formula: FNa
Molar mass (g/mol): 41.9882
Exact mass (Da): 41.9882
H-bond donors: 0
H-bond acceptors: 1
Rotatable bonds: 0
Heavy atoms: 2
InChIKey: PUZPDOWCWNUUKD-UHFFFAOYSA-M
PubChem record: CID 5235 ↗
IUPAC name: sodium fluoride
SMILES: [F-].[Na+]

Radiolabelled forms

Form	Use	Molar mass (labelled form)	Ongoing trials	Most advanced phase	Approval
Na[¹⁸F]F Syntheses and QC ↗	Imaging	40.99	5	Phase 2	[18F]NaF (CISNAF, NaF MetaTrace…) US EU FR

Ongoing trials · 5Open in the radar →

Atlas trials whose studied drug or title names this vector, with this radionuclide.

Trial	Phase	Status	Sponsor	Countries
[18F]DCFPyL (piflufolastat)NCT03173924 · Prostate – other	Phase 2	Active, not recruiting	National Cancer Institute (NCI)	1
[18F]NaFNCT07284563 · Bacterial infections	Phase 2	Recruiting	Akiva Mintz	1
[18F]NaF2024-514759-13-01 · Inflammatory diseases	Phase 2	Recruiting	Stichting Amsterdam UMC	1
[18F]FDGNCT06914999 · Atherosclerosis and vessels	Phase 1	Recruiting	Emory University	1
SPECTRE · [18F]NaFNCT06013722 · Ischemic heart disease	No phase	Active, not recruiting	Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer	1

PublicationsAll publications in PubMed ↗

708 publications in PubMed for the query below; the most recent:

"sodium fluoride"[tiab] AND (PET[tiab] OR "18F"[tiab])

Advanced imaging in systemic sclerosis: distinguishing activity from damage across organ systems Curr Opin Rheumatol, 2026
What is the Utility of Whole Body Imaging for Screening Patients With Craniofacial Fibrous Dysplasia? J Craniofac Surg, 2026
Subclinical Leaflet Thrombosis, Transcatheter Heart Valve Characteristics and Structural Valve Deterioration: Rationale and Design of the POPular PET TAVI Study J Nucl Cardiol, 2026
Macrophage-mediated inflammation and microcalcification are associated with abdominal aortic aneurysm progression and clinical events Br J Surg, 2026
¹⁸F-sodium fluoride PET/CT as a complementary measure of osteoblastic disease burden in axial spondyloarthritis: a prospective exploratory study Eur J Nucl Med Mol Imaging, 2026
Molecular imaging of atherosclerotic plaque vulnerability: a narrative review Int J Cardiovasc Imaging, 2026
Quantitative assessment of active charcot neuro-osteoarthropathy in diabetes using (18)F-sodium fluoride PET/CT Front Endocrinol (Lausanne), 2026
The value of (18)F-fluoride PET in bone metastases: an overview Semin Nucl Med, 2026

Sources: PubChem and PubMed (NCBI), ClinicalTrials.gov and CTIS registries, approvals recorded by the atlas. PubChem data as of 28 October 2026.

Cite this page

Sodium fluoride. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 27 October 2026. https://theranosticatlas.com/molecule/fluoride/ (accessed [date]).

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