Molecules

FET

Target Amino acid transportClass Amino acid (tyrosine derivative)Other names O-(2-fluoroethyl)-L-tyrosine, floretyrosine

9ongoing trials
1radiolabelled forms
1approved products
691publications (PubMed)

Structure

Structure from the cited PubChem record (unlabelled ligand, or the labelled form when PubChem only describes that one). Conformer: PubChem (3D conformer computed by PubChem). Rotate with the mouse or a finger.

Properties (PubChem)

Molecular formula
C11H14FNO3
Molar mass (g/mol)
227.23
Exact mass (Da)
227.0958
XLogP
-0.8
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
16
InChIKey
QZZYPHBVOQMBAT-JTQLQIEISA-N
PubChem record
CID 54255856 ↗
IUPAC name
(2S)-2-amino-3-[4-(2-fluoroethoxy)phenyl]propanoic acid
SMILES
C1=CC(=CC=C1C[C@@H](C(=O)O)N)OCCF

Radiolabelled forms

FormUseMolar mass (labelled form)Ongoing trialsMost advanced phaseApproval
[¹⁸F]FET Syntheses and QC ↗Imaging226.239Phase 3FET (Pixclara, IASOglio) US EU FR

Ongoing trials · 9Open in the radar →

Atlas trials whose studied drug or title names this vector, with this radionuclide.

TrialPhaseStatusSponsorCountries
[18F]FETNCT07698457 · Brain (glioma, medulloblastoma…)Phase 3Not yet recruitingPrimo Biotechnology Co., Ltd1
FET-PIT · [18F]FETNCT07360548 · OtherPhase 2Not yet recruitingUniversity Hospital, Lille1
FET PET in HGG · [18F]FETNCT06172595 · Brain (glioma, medulloblastoma…)Phase 2RecruitingSingapore General Hospital1
[18F]FETNCT07456878 · OtherPhase 1RecruitingMayo Clinic1
[18F]FETNCT05632562 · Brain (glioma, medulloblastoma…)Phase 1RecruitingUniversity of Alabama at Birmingham1
FET-POPPING · [18F]FETNCT06480721 · Brain (glioma, medulloblastoma…)No phaseNot yet recruitingVeerle Ruijters1
[18F]FETNCT07475390 · Brain (glioma, medulloblastoma…)No phaseActive, not recruitingTomsk National Research Medical Center of the Russian Academy of Sciences1
FIND · [18F]FETNCT07108244 · AdrenalNo phaseBy invitationUniversity Hospital, Basel, Switzerland2
FET-pit-PET · [18F]FETNCT06584123 · OtherNo phaseRecruitingUniversity of Cambridge1
Other trials listing it among the interventions (comparator, associated scan) · 1
[68Ga]Ga-DOTA-TATE/TOC/NOCNCT07366710 · OtherNo phaseActive, not recruitingCopenhagen University Hospital, Rigshospitalet1

Published results · 1

2026-09FIG (TROG 18.06) · positiveIn 140 patients with newly diagnosed glioblastoma, adding FET PET to MRI enlarges the radiotherapy target volume in 83% of cases. The change is clinically significant in 76% of patients; the impact on tumor control remains to be shown.Neuro Oncol ↗

PublicationsAll publications in PubMed ↗

691 publications in PubMed for the query below; the most recent:

"fluoroethyl-L-tyrosine"[tiab] OR "FET PET"[tiab] OR floretyrosine[tiab] OR "18F-FET"[tiab]

  1. 18 F-FET PET Pitfall in Pituitary Imaging: False-positive Uptake Due to Neurosarcoidosis Clin Nucl Med, 2026
  2. Volumetric discordance between ¹⁸F-FET-PET/MRI and MRI-based radiotherapy target volumes in high-grade glioma: a prospective pilot study (FETSMaRT) J Neurooncol, 2026
  3. Beyond a Universal Cut-Off: [(18)F]FET-PET Metrics for Distinguishing High-Grade Glioma Recurrence from Treatment-Related Changes Brain Sci, 2026
  4. [(18)F]FET uptake in diffuse lower-grade IDH-mutant glioma correlates with glioma-related epilepsy J Neurooncol, 2026
  5. False-Positive [¹⁸F]FET-Uptake in a Developmental Venous Anomaly: A Diagnostic Pitfall Clin Nucl Med, 2026
  6. Rhinocerebral mucormycosis: a potential source of false-positive uptake on [(18)F]FET PET/MR leading to diagnostic ambiguity Eur J Nucl Med Mol Imaging, 2026
  7. Impact of [18F]FET-PET on MRI-Based Radiotherapy Target Volumes in Newly Diagnosed Glioblastoma:Results from the FET-PET in Glioblastoma (FIG) Study TROG 18.06 Neuro Oncol, 2026
  8. PET|MR Open Source Radiomics Models for Treatment Outcome Prediction in Recurrent GBM Cancers (Basel), 2026

Sources: PubChem and PubMed (NCBI), ClinicalTrials.gov and CTIS registries, approvals recorded by the atlas. PubChem data as of 28 October 2026.

Cite this page

FET. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 27 October 2026. https://theranosticatlas.com/molecule/fet/ (accessed [date]).

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