Molecules

Fluoroestradiol

Target Estrogen receptorsClass Steroid (estradiol analogue)Other names FES, 16α-fluoroestradiol

12ongoing trials
1radiolabelled forms
1approved products
335publications (PubMed)

Structure

Structure from the cited PubChem record (unlabelled ligand, or the labelled form when PubChem only describes that one). Conformer: PubChem (3D conformer computed by PubChem). Rotate with the mouse or a finger.

Properties (PubChem)

Molecular formula
C18H23FO2
Molar mass (g/mol)
290.4
Exact mass (Da)
290.1682
XLogP
3.5
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
0
Heavy atoms
21
InChIKey
KDLLNMRYZGUVMA-ZXXIGWHRSA-N
PubChem record
CID 10401972 ↗
IUPAC name
(8R,9S,13S,14S,16R,17R)-16-fluoro-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H]([C@@H]2O)F)CCC4=C3C=CC(=C4)O

Radiolabelled forms

FormUseMolar mass (labelled form)Ongoing trialsMost advanced phaseApproval
[¹⁸F]FES Syntheses and QC ↗Imaging289.412Phase 2Cerianna / EstroTep US EU FR

Ongoing trials · 12Open in the radar →

Atlas trials whose studied drug or title names this vector, with this radionuclide.

TrialPhaseStatusSponsorCountries
[18F]FESNCT02398773 · BreastPhase 2Active, not recruitingNational Cancer Institute (NCI)1
FESTA · [18F]FESNCT05982496 · BreastPhase 2RecruitingUniversità Vita-Salute San Raffaele1
[18F]FESNCT07314073 · BreastPhase 2RecruitingAsan Medical Center1
[18F]FESNCT04824014 · BreastPhase 2RecruitingCentre de recherche du Centre hospitalier universitaire de Sherbrooke1
[18F]FESNCT04692103 · BreastPhase 2Active, not recruitingUniversity of Washington1
[18F]FESNCT05916196 · GynecologicalPhase 2RecruitingAbramson Cancer Center at Penn Medicine1
[18F]FESNCT05659797 · BreastPhase 1RecruitingAbramson Cancer Center at Penn Medicine1
ESTROTIMP · [18F]FESNCT05486182 · BreastNo phaseActive, not recruitingGE Healthcare1
IMPACT-MBC · [18F]FESNCT01957332 · BreastNo phaseActive, not recruitingUniversity Medical Center Groningen1
[18F]FESNCT07627269 · BreastNo phaseNot yet recruitingUniversity Medical Center Groningen1
ENDO-TEP · [18F]FESNCT07053982 · GynecologicalNo phaseRecruitingUniversity Hospital, Toulouse1
FEStastic · [18F]FESNCT05088785 · BreastNo phaseActive, not recruitingAmsterdam UMC, location VUmc1
Other trials listing it among the interventions (comparator, associated scan) · 1
SONImage · [18F]FDGNCT04125277 · BreastNo phaseActive, not recruitingThe Netherlands Cancer Institute1

PublicationsAll publications in PubMed ↗

335 publications in PubMed for the query below; the most recent:

fluoroestradiol[tiab] OR "FES PET"[tiab]

  1. Utilization of (18)F-Fluoroestradiol for Clinical Field Design and Dose Determination in Breast Radiation Therapy Adv Radiat Oncol, 2026
  2. Imaging patterns and diagnostic challenges in metastatic invasive lobular carcinoma Eur J Radiol, 2026
  3. Steroidal scaffolds in radiopharmaceutical chemistry: Synthetic strategies, receptor targeting, and theranostic applications Eur J Med Chem, 2026
  4. Discordant (18)F-FES PET and ER immunohistochemistry in ER-positive bone metastasis: a potential imaging pitfall Eur J Nucl Med Mol Imaging, 2026
  5. Dynamic Brain [(18)F] Fluoroestradiol PET Protocol Optimization for Improved Detection of Breast Cancer Brain Metastases AJNR Am J Neuroradiol, 2026
  6. Clinical Utility of [(18)F]Fluoroestradiol PET/CT to Guide Second Line Treatment Decision in ER-Positive HER2-Negative Metastatic Breast Cancer After Progression on First Line Endocrine Therapy Clin Breast Cancer, 2026
  7. Incidental Thyroid Uptake on 18F-FES PET/CT Revealing Papillary Thyroid Carcinoma Clin Nucl Med, 2026
  8. Design and imaging performance of BPET-DBT - a dedicated scanner for breast imaging Med Phys, 2026

Sources: PubChem and PubMed (NCBI), ClinicalTrials.gov and CTIS registries, approvals recorded by the atlas. PubChem data as of 28 October 2026.

Cite this page

Fluoroestradiol. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 27 October 2026. https://theranosticatlas.com/molecule/fes/ (accessed [date]).

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