Estrogen receptors

Ongoing clinical trials and approved products targeting Estrogen receptors, in radioligand therapy and PET/SPECT imaging. Data as of 26 October 2026.

0ongoing therapy trials

11ongoing imaging trials

1approved products

Target note

Full name: Estrogen receptors (ER-α)
Nature: Nuclear receptor for estradiol, target of hormone therapy.
Normal expression: Liver (metabolism), uterus, ovaries.
Disease expression: About 70% of breast cancers.
Value: Measuring functional ER expression across all lesions, useful when a biopsy is difficult or the status may have changed; predicting response to hormone therapy.
Approaches: [18F]FES (Cerianna, EstroTep).
Indications explored: Recurrent or metastatic breast cancer, gynecological cancers.
Points of caution: Treatments that block ER (fulvestrant, tamoxifen) abolish uptake; the liver cannot be assessed.

Approved products

Cerianna / EstroTep[18F]fluoroestradiol (FES)

GE HealthCare (US), Zionexa (France)

marketed

US EU FR

Ongoing imaging trials · 11Open in the radar →

Trial	Phase	Status	Sponsor	Countries
[18F]FESNCT02398773 · Breast	Phase 2	Active, not recruiting	National Cancer Institute (NCI)	1
FESTA · [18F]FESNCT05982496 · Breast	Phase 2	Recruiting	Università Vita-Salute San Raffaele	1
[18F]FESNCT07314073 · Breast	Phase 2	Recruiting	Asan Medical Center	1
[18F]FESNCT04824014 · Breast	Phase 2	Recruiting	Centre de recherche du Centre hospitalier universitaire de Sherbrooke	1
[18F]FESNCT05916196 · Gynecological	Phase 2	Recruiting	Abramson Cancer Center at Penn Medicine	1
[18F]FESNCT05659797 · Breast	Phase 1	Recruiting	Abramson Cancer Center at Penn Medicine	1
ESTROTIMP · [18F]FESNCT05486182 · Breast	No phase	Active, not recruiting	GE Healthcare	1
IMPACT-MBC · [18F]FESNCT01957332 · Breast	No phase	Active, not recruiting	University Medical Center Groningen	1
[18F]FESNCT07627269 · Breast	No phase	Not yet recruiting	University Medical Center Groningen	1
ENDO-TEP · [18F]FESNCT07053982 · Gynecological	No phase	Recruiting	University Hospital, Toulouse	1
FEStastic · [18F]FESNCT05088785 · Breast	No phase	Active, not recruiting	Amsterdam UMC, location VUmc	1

Cite this page

Estrogen receptors. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 26 October 2026. https://theranosticatlas.com/target/estrogen-receptors/ (accessed [date]).

A monitoring tool with no regulatory value: check every item at its source.