Ongoing clinical trials and approved products targeting FAP, in radioligand therapy and PET/SPECT imaging. Data as of 26 October 2026.
Theranostic pair: this target is explored in both imaging and therapy.
| Trial | Phase | Status | Sponsor | Countries |
|---|---|---|---|---|
| LuMIERE · [177Lu]FAP-2286NCT04939610 · Solid tumors (multiple indications) | Phase 2 | Recruiting | Novartis Pharmaceuticals | 6 |
| [212Pb]Pb-PSV359NCT06710756 · Pancreas (adenocarcinoma) | Phase 2 | Recruiting | Perspective Therapeutics | 1 |
| Lu-FAP CUP · [177Lu]FAP-2286NCT07434180 · Solid tumors (multiple indications) | Phase 2 | Not yet recruiting | Peter MacCallum Cancer Centre, Australia | 1 |
| Yttrium-90-Labeled Fibroblast Activation Protein Inhibitor (Y-90 FAPI)NCT07500285 · Small-cell lung cancer | Phase 2 | Not yet recruiting | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization | 1 |
| FAUNUS · [177Lu]FAP-2286NCT06880757 · Bladder / urothelial | Phase 2 | Not yet recruiting | Ankara University | 0 |
| Injection of 177Lu-NI-FAPINCT07822347 · Solid tumors (multiple indications) | Phase 2 | By invitation | Peking Union Medical College Hospital | 1 |
| ATLAS · [225Ac]RTX-2358NCT07156565 · Sarcoma / bone | Phase 1 | Recruiting | Ratio Therapeutics, Inc. | 2 |
| [177Lu]IM-3050NCT07505771 · Solid tumors (multiple indications) | Phase 1 | Recruiting | Immunome, Inc. | 1 |
| 177Lu-NRT6020 Injection (stage 2)NCT06911489 · Solid tumors (multiple indications) | Phase 1 | Recruiting | Chengdu New Radiomedicine Technology Co. LTD. | 1 |
| TheraTri · [177Lu]Lu-OncoFAP-23NCT06640413 · Solid tumors (multiple indications) | Phase 1 | Recruiting | Philogen S.p.A. | 1 |
| [177Lu]Lu-RTX-2358NCT07689643 · Small-cell lung cancer | Phase 1 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 1 |
| [177Lu]Lu-XT117NCT06197139 · Solid tumors (multiple indications) | Phase 1 | Recruiting | Xinlu Wang | 1 |
| [177Lu]Lu-XT117NCT06211647 · Solid tumors (multiple indications) | Phase 1 | Recruiting | Ruimin Wang | 1 |
| 225Ac-FAPI-XTNCT07135128 · Solid tumors (multiple indications) | Phase 1 | Recruiting | Xiaorong Sun | 1 |
| 68Ga-FAPI-RGD for PET / CT scan and 177Lu-FAPI-RGD for therapyNCT06638034 · Solid tumors (multiple indications) | Phase 1 | Recruiting | Peking Union Medical College Hospital | 1 |
| 177Lu-CTR-FAPI therapyNCT07438847 · Thyroid | Phase 1 | Recruiting | SHAOYAN LIU | 1 |
| 177Lu-CTR-FAPINCT07229768 · Pancreas (adenocarcinoma) | Phase 1 | Recruiting | Yan Xing | 1 |
| 177Lu-JH040182 with an activity of approximately 5.55-7.50 GBqNCT07681141 · Solid tumors (multiple indications) | Phase 1 | Active, not recruiting | First Affiliated Hospital of Fujian Medical University | 1 |
| 177Lu-FAP-VG11NCT07808177 · Solid tumors (multiple indications) | Phase 1 | Recruiting | Shandong Cancer Hospital and Institute | 1 |
| 177Lu-AF03NCT07879547 · Solid tumors (multiple indications) | Phase 1 | Not yet recruiting | Yong He | 1 |
| Trial | Phase | Status | Sponsor | Countries |
|---|---|---|---|---|
| FAPI-GO · FAP ligands (FAPI)NCT07217704 · Stomach / esophagus | Phase 3 | Recruiting | SOFIE | 1 |
| FAPI-PRO · FAP ligands (FAPI)NCT07217717 · Pancreas (adenocarcinoma) | Phase 3 | Recruiting | SOFIE | 1 |
| FAP ligands (FAPI)2023-506030-70-00 · Pancreas (adenocarcinoma) | Phase 3 | Not yet recruiting | Universitaetsklinikum Essen AöR | 1 |
| FAPIChol · FAP ligands (FAPI)NCT06355427 · Solid tumors (multiple indications) | Phase 3 | Recruiting | Mara Veenstra, MD | 1 |
| FAP ligands (FAPI)NCT07535554 · Bacterial infections | Phase 3 | Recruiting | Universitaire Ziekenhuizen KU Leuven | 1 |
| FAP ligands (FAPI)NCT07098598 · Pancreas (adenocarcinoma) | Phase 3 | Recruiting | Turku University Hospital | 1 |
| FAP ligands (FAPI)NCT07272772 · Colorectal | Phase 3 | Recruiting | Turku University Hospital | 1 |
| FAP ligands (FAPI)NCT07613099 · Atherosclerosis and vessels | Phase 3 | Recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 1 |
| FAP ligands (FAPI)2024-516486-36-00 · Pancreas (adenocarcinoma) | Phase 3 | Recruiting | Stichting Amsterdam UMC | 1 |
| FAP ligands (FAPI)2026-526942-29-00 · Inflammatory diseases | Phase 3 | Not yet recruiting | UZ Leuven | 1 |
| PLASTIC-3 · FAP ligands (FAPI)NCT07018661 · Stomach / esophagus | Phase 3 | Recruiting | Leiden University Medical Center | 1 |
| FAP ligands (FAPI)2024-517931-29-00 · Inflammatory diseases | Phase 3 | Recruiting | Universitair Medisch Centrum Groningen | 1 |
| FAPIDO · FAP ligands (FAPI)NCT06782412 · Pancreas (adenocarcinoma) | Phase 3 | Recruiting | KU Leuven | 1 |
| FAP ligands (FAPI)2025-520731-17-02 · Other | Phase 3 | Not yet recruiting | Centre Hospitalier Regional Et Universitaire De Brest | 1 |
| FAP ligands (FAPI)2024-517257-27-00 · Other | Phase 3 | Recruiting | Universitair Medisch Centrum Groningen | 1 |
| FAP ligands (FAPI)NCT07702292 · Breast | Phase 2 | Recruiting | Blue Earth Diagnostics | 2 |
| FAP ligands (FAPI)NCT07432633 · Breast | Phase 2 | Recruiting | Blue Earth Diagnostics | 1 |
| FAP ligands (FAPI)NCT05518903 · Pancreas (adenocarcinoma) | Phase 2 | Recruiting | Mayo Clinic | 1 |
| BEFAST · FAP ligands (FAPI)NCT07629609 · Pancreas (adenocarcinoma) | Phase 2 | Recruiting | Barbara Malene Fischer | 1 |
| FAPIPET · FAP ligands (FAPI)NCT07705074 · Inflammatory diseases | Phase 2 | Not yet recruiting | Martin Huellner | 1 |
| FAP ligands (FAPI)2024-518765-96-00 · Solid tumors (multiple indications) | Phase 2 | Recruiting | Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico | 1 |
| FAPI-NICM · FAP ligands (FAPI)NCT07878338 · Ischemic heart disease | Phase 2 | Recruiting | Peking Union Medical College Hospital | 1 |
| FAP ligands (FAPI)NCT06503146 · Pheochromocytoma / paraganglioma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 1 |
| FAPI-PM · FAP ligands (FAPI)NCT06790082 · Solid tumors (multiple indications) | Phase 2 | Recruiting | Aalborg University Hospital | 1 |
| FAP ligands (FAPI)NCT07083011 · Heart failure and cardiomyopathies | Phase 2 | Recruiting | Mayo Clinic | 1 |
| PHANTOM · FAP ligands (FAPI)NCT06298916 · Pancreas (adenocarcinoma) | Phase 2 | Recruiting | Lantheus Medical Imaging | 1 |
| FAP ligands (FAPI)NCT06335069 · Breast | Phase 2 | Recruiting | Maastricht University Medical Center | 1 |
| FAP ligands (FAPI)2024-511659-17-00 · Solid tumors (multiple indications) | Phase 2 | Recruiting | Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l. | 1 |
| FAP ligands (FAPI)2024-514504-13-00 · Inflammatory diseases | Phase 2 | Recruiting | MoonLake Immunotherapeutics AG | 1 |
| FAP ligands (FAPI)NCT07523607 · Breast | Phase 2 | Not yet recruiting | Odense University Hospital | 0 |
| FAP ligands (FAPI)2023-503686-26-02 · Inflammatory diseases | Phase 2 | Recruiting | St Antonius Hospital | 1 |
| FAPDIG · FAP ligands (FAPI)NCT07478523 · Pancreas (adenocarcinoma) | Phase 2 | Recruiting | University Hospital, Bordeaux | 1 |
| FAPICAM · FAP ligands (FAPI)NCT07549841 · Cardiac amyloidosis | Phase 2 | Recruiting | Nantes University Hospital | 1 |
| HEFITEP · FAP ligands (FAPI)NCT06160271 · Psychiatry and addiction | Phase 2 | Not yet recruiting | Central Hospital, Nancy, France | 0 |
| FAP ligands (FAPI)NCT07062523 · Inflammatory diseases | Phase 2 | Recruiting | Peking Union Medical College Hospital | 1 |
| FAPIHN · FAP ligands (FAPI)NCT06794372 · Head and neck | Phase 2 | Recruiting | John O. Prior | 1 |
| BEFAST · FAP ligands (FAPI)NCT07215182 · Melanoma | Phase 2 | Recruiting | Barbara Malene Fischer | 1 |
| FAP ligands (FAPI)2025-524874-41-00 · Sarcoma / bone | Phase 2 | Not yet recruiting | Rigshospitalet | 1 |
| FAP ligands (FAPI)2024-511977-31-01 · Atherosclerosis and vessels | Phase 2 | Not yet recruiting | Universitair Medisch Centrum Groningen | 1 |
| MI-CISDIR · FAP ligands (FAPI)NCT06540872 · Breast | Phase 2 | Recruiting | Universität Münster | 1 |
| INDIGO-FAPI · FAP ligands (FAPI)NCT06659705 · Pancreas (adenocarcinoma) | Phase 2 | Recruiting | Institut Curie | 1 |
| FAP ligands (FAPI)2025-524897-40-00 · Breast | Phase 2 | Not yet recruiting | Hospices Civils De Lyon | 1 |
| SOFAPI · FAP ligands (FAPI)NCT07357974 · Other | Phase 2 | Not yet recruiting | University Hospital, Brest | 1 |
| FAP ligands (FAPI)2025-524434-25-00 · Stomach / esophagus | Phase 2 | Not yet recruiting | Centre Hospitalier Universitaire De Bordeaux | 1 |
| FAP ligands (FAPI)NCT07285993 · Breast | Phase 2 | Not yet recruiting | Randy Yeh | 1 |
| FAP ligands (FAPI)2025-521163-12-01 · Thyroid | Phase 2 | Not yet recruiting | Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) | 1 |
| FAP ligands (FAPI)NCT07464132 · Heart failure and cardiomyopathies | Phase 2 | Recruiting | Peking Union Medical College Hospital | 1 |
| FAP ligands (FAPI)2025-523032-39-00 · Small-cell lung cancer | Phase 2 | Not yet recruiting | Academisch Ziekenhuis Maastricht | 1 |
| FAP ligands (FAPI)NCT05172310 · Pancreas (adenocarcinoma) | Phase 1 | Recruiting | Karolinska University Hospital | 1 |
| FAP ligands (FAPI)NCT04499365 · Solid tumors (multiple indications) | Phase 1 | Recruiting | First Affiliated Hospital of Fujian Medical University | 1 |
| FAP ligands (FAPI)NCT06740240 · Solid tumors (multiple indications) | Phase 1 | Recruiting | First Affiliated Hospital of Fujian Medical University | 1 |
| FAP ligands (FAPI)2023-506594-35-00 · Colorectal | Phase 1 | Recruiting | Amsterdam UMC | 1 |
| FAP ligands (FAPI)NCT04621435 · Solid tumors (multiple indications) | Phase 1 | Recruiting | Thomas Hope | 1 |
| FAP ligands (FAPI)NCT07144085 · Solid tumors (multiple indications) | Phase 1 | Recruiting | Yi Tian | 1 |
| FAP ligands (FAPI)NCT05121779 · Inflammatory diseases | Phase 1 | Recruiting | Peking Union Medical College Hospital | 1 |
| FAP ligands (FAPI)2024-518838-82-00 · Inflammatory diseases | Phase 1 | Recruiting | Universitair Medisch Centrum Groningen | 1 |
| FAP ligands (FAPI)NCT06413355 · Inflammatory diseases | Phase 1 | Recruiting | Abramson Cancer Center at Penn Medicine | 1 |
| FAPI-PETCD · FAP ligands (FAPI)NCT07273188 · Inflammatory diseases | Phase 1 | Recruiting | Mayo Clinic | 1 |
| FAP ligands (FAPI)NCT07457541 · Breast | Phase 1 | Active, not recruiting | Tomsk National Research Medical Center of the Russian Academy of Sciences | 1 |
| FAP ligands (FAPI)NCT06688305 · Solid tumors (multiple indications) | Phase 1 | Recruiting | First Affiliated Hospital of Fujian Medical University | 1 |
| FAP ligands (FAPI)2023-505317-25-00 · Inflammatory diseases | Phase 1 | Recruiting | Amsterdam UMC | 1 |
| FAPI PET Prost · FAP ligands (FAPI)NCT04457232 · Prostate – other | Phase 1 | Active, not recruiting | Jonsson Comprehensive Cancer Center | 1 |
| FAPI ILD · FAP ligands (FAPI)NCT05365802 · Inflammatory diseases | Phase 1 | Active, not recruiting | University of California, Los Angeles | 1 |
| FAP ligands (FAPI)NCT07118176 · Prostate – other | Phase 1 | Active, not recruiting | Jonsson Comprehensive Cancer Center | 1 |
| FAP ligands (FAPI)NCT07132645 · NETs and neuroendocrine carcinomas (other) | Phase 1 | Recruiting | University of Michigan Rogel Cancer Center | 1 |
| FAP ligands (FAPI)NCT07817563 · Non-small-cell lung cancer | Phase 1 | Not yet recruiting | Mayo Clinic | 1 |
| FAPI PET RDRC · FAP ligands (FAPI)NCT04459273 · NETs and neuroendocrine carcinomas (other) | Phase 1 | Active, not recruiting | Jonsson Comprehensive Cancer Center | 1 |
| FAP ligands (FAPI)2023-503985-21-00 · Small-cell lung cancer | Phase 1 | Recruiting | Meander Medisch Centrum | 1 |
| FAP ligands (FAPI)NCT04457258 · Sarcoma / bone | Phase 1 | Active, not recruiting | Jonsson Comprehensive Cancer Center | 1 |
| FAP ligands (FAPI)NCT06734572 · Solid tumors (multiple indications) | Phase 1 | Recruiting | First Affiliated Hospital of Fujian Medical University | 1 |
| FAP ligands (FAPI)NCT07830771 · Bacterial infections | Phase 1 | Recruiting | University of Pennsylvania | 1 |
| CUPCAKE · FAP ligands (FAPI)NCT06225505 · Breast | No phase | Recruiting | Institut Curie | 1 |
| FAP ligands (FAPI)NCT05034146 · Solid tumors (multiple indications) | No phase | Recruiting | Zhongnan Hospital | 1 |
| FAP ligands (FAPI)NCT06421142 · Bladder / urothelial | No phase | Recruiting | First Affiliated Hospital of Fujian Medical University | 1 |
| FAP ligands (FAPI)NCT04416165 · Solid tumors (multiple indications) | No phase | Recruiting | The First Affiliated Hospital of Xiamen University | 1 |
| FAP ligands (FAPI)NCT07753499 · Thyroid | No phase | Recruiting | The First Affiliated Hospital of Xiamen University | 1 |
| PARADISE · FAP ligands (FAPI)NCT06275477 · Inflammatory diseases | No phase | Recruiting | University Hospital, Brest | 1 |
| FAP ligands (FAPI)NCT07180433 · Breast | No phase | Not yet recruiting | St. Olavs Hospital | 0 |
| EM-FAPI · FAP ligands (FAPI)NCT07876648 · Inflammatory diseases | No phase | Recruiting | Universitaire Ziekenhuizen KU Leuven | 1 |
| FAP ligands (FAPI)NCT06232122 · Gynecological | No phase | Recruiting | Chang Gung Memorial Hospital | 1 |
| FAP ligands (FAPI)NCT06791226 · Solid tumors (multiple indications) | No phase | Recruiting | Peking University Third Hospital | 1 |
| FAP ligands (FAPI)NCT05442151 · Solid tumors (multiple indications) | No phase | Recruiting | Tadashi Watabe | 1 |
| FAP ligands (FAPI)NCT06653452 · Colorectal | No phase | Recruiting | Peking Union Medical College Hospital | 1 |
| Ga-68-FAPI-46 · FAP ligands (FAPI)NCT06769828 · Colorectal | No phase | Recruiting | Koo Foundation Sun Yat-Sen Cancer Center | 1 |
| PKUCH-R12 · FAP ligands (FAPI)NCT07552207 · Colorectal | No phase | Not yet recruiting | Peking University Cancer Hospital & Institute | 0 |
| FAP ligands (FAPI)NCT06911021 · Pancreas (adenocarcinoma) | No phase | Not yet recruiting | Centre Hospitalier Universitaire Vaudois | 1 |
| FAPeCa · FAP ligands (FAPI)NCT06061874 · Solid tumors (multiple indications) | No phase | Recruiting | Jules Bordet Institute | 1 |
| INTERACT-FAPI · FAP ligands (FAPI)NCT06957782 · Other | No phase | Not yet recruiting | Erasmus Medical Center | 0 |
| FAP ligands (FAPI)NCT07114211 · Other | No phase | Not yet recruiting | Xijing Hospital | 0 |
| FAP ligands (FAPI)NCT05140746 · Stomach / esophagus | No phase | Recruiting | Ruijin Hospital | 1 |
| FAP-IT · FAP ligands (FAPI)NCT06349512 · Breast | No phase | Recruiting | Institut Curie | 1 |
| FAPI-PET · FAP ligands (FAPI)NCT06790264 · Breast | No phase | Recruiting | European Institute of Oncology | 1 |
| FAPI for CUP · FAP ligands (FAPI)NCT06644716 · Solid tumors (multiple indications) | No phase | Recruiting | Erasmus Medical Center | 1 |
| FoCus · FAP ligands (FAPI)NCT06191120 · Colorectal | No phase | Recruiting | UMC Utrecht | 1 |
| FAP ligands (FAPI)NCT07104058 · Inflammatory diseases | No phase | Recruiting | Luo Yaping | 1 |
| FAP ligands (FAPI)NCT07423013 · Thyroid | No phase | Recruiting | Peking University Third Hospital | 1 |
| FAPI-ARVC · FAP ligands (FAPI)NCT07563660 · Heart failure and cardiomyopathies | No phase | Recruiting | Istanbul University - Cerrahpasa | 1 |
| GALILEE · FAP ligands (FAPI)NCT05931302 · Breast | No phase | Active, not recruiting | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer | 1 |
| FAST HOC · FAP ligands (FAPI)NCT05956093 · Gynecological | No phase | Active, not recruiting | University Health Network, Toronto | 1 |
| FAP ligands (FAPI)NCT06684028 · Solid tumors (multiple indications) | No phase | Recruiting | Affiliated Hospital of Jiangnan University | 1 |
| FAP ligands (FAPI)NCT07138729 · Inflammatory diseases | No phase | Recruiting | Luo Yaping | 1 |
FAP. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 26 October 2026. https://theranosticatlas.com/target/fap/ (accessed [date]).
A monitoring tool with no regulatory value: check every item at its source.