Essais cliniques en cours et produits autorisés visant FAP, en radiothérapie interne vectorisée et en imagerie TEP/TEMP. Données du 26 octobre 2026.
Paire théranostique : cette cible est explorée à la fois en imagerie et en thérapie.
| Essai | Phase | Statut | Promoteur | Pays |
|---|---|---|---|---|
| LuMIERE · [177Lu]FAP-2286NCT04939610 · Tumeurs solides (multi-indications) | Phase 2 | Recrute | Novartis Pharmaceuticals | 6 |
| [212Pb]Pb-PSV359NCT06710756 · Pancréas (adénocarcinome) | Phase 2 | Recrute | Perspective Therapeutics | 1 |
| Lu-FAP CUP · [177Lu]FAP-2286NCT07434180 · Tumeurs solides (multi-indications) | Phase 2 | Pas encore ouvert | Peter MacCallum Cancer Centre, Australia | 1 |
| Yttrium-90-Labeled Fibroblast Activation Protein Inhibitor (Y-90 FAPI)NCT07500285 · Poumon à petites cellules | Phase 2 | Pas encore ouvert | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization | 1 |
| FAUNUS · [177Lu]FAP-2286NCT06880757 · Vessie / urothélial | Phase 2 | Pas encore ouvert | Ankara University | 0 |
| Injection of 177Lu-NI-FAPINCT07822347 · Tumeurs solides (multi-indications) | Phase 2 | Sur invitation | Peking Union Medical College Hospital | 1 |
| ATLAS · [225Ac]RTX-2358NCT07156565 · Sarcome / os | Phase 1 | Recrute | Ratio Therapeutics, Inc. | 2 |
| [177Lu]IM-3050NCT07505771 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | Immunome, Inc. | 1 |
| 177Lu-NRT6020 Injection (stage 2)NCT06911489 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | Chengdu New Radiomedicine Technology Co. LTD. | 1 |
| TheraTri · [177Lu]Lu-OncoFAP-23NCT06640413 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | Philogen S.p.A. | 1 |
| [177Lu]Lu-RTX-2358NCT07689643 · Poumon à petites cellules | Phase 1 | Recrute | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 1 |
| [177Lu]Lu-XT117NCT06197139 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | Xinlu Wang | 1 |
| [177Lu]Lu-XT117NCT06211647 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | Ruimin Wang | 1 |
| 225Ac-FAPI-XTNCT07135128 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | Xiaorong Sun | 1 |
| 68Ga-FAPI-RGD for PET / CT scan and 177Lu-FAPI-RGD for therapyNCT06638034 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | Peking Union Medical College Hospital | 1 |
| 177Lu-CTR-FAPI therapyNCT07438847 · Thyroïde | Phase 1 | Recrute | SHAOYAN LIU | 1 |
| 177Lu-CTR-FAPINCT07229768 · Pancréas (adénocarcinome) | Phase 1 | Recrute | Yan Xing | 1 |
| 177Lu-JH040182 with an activity of approximately 5.55-7.50 GBqNCT07681141 · Tumeurs solides (multi-indications) | Phase 1 | Actif, ne recrute plus | First Affiliated Hospital of Fujian Medical University | 1 |
| 177Lu-FAP-VG11NCT07808177 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | Shandong Cancer Hospital and Institute | 1 |
| 177Lu-AF03NCT07879547 · Tumeurs solides (multi-indications) | Phase 1 | Pas encore ouvert | Yong He | 1 |
| Essai | Phase | Statut | Promoteur | Pays |
|---|---|---|---|---|
| FAPI-GO · Ligands FAP (FAPI)NCT07217704 · Estomac / œsophage | Phase 3 | Recrute | SOFIE | 1 |
| FAPI-PRO · Ligands FAP (FAPI)NCT07217717 · Pancréas (adénocarcinome) | Phase 3 | Recrute | SOFIE | 1 |
| Ligands FAP (FAPI)2023-506030-70-00 · Pancréas (adénocarcinome) | Phase 3 | Pas encore ouvert | Universitaetsklinikum Essen AöR | 1 |
| FAPIChol · Ligands FAP (FAPI)NCT06355427 · Tumeurs solides (multi-indications) | Phase 3 | Recrute | Mara Veenstra, MD | 1 |
| Ligands FAP (FAPI)NCT07535554 · Infections bactériennes | Phase 3 | Recrute | Universitaire Ziekenhuizen KU Leuven | 1 |
| Ligands FAP (FAPI)NCT07098598 · Pancréas (adénocarcinome) | Phase 3 | Recrute | Turku University Hospital | 1 |
| Ligands FAP (FAPI)NCT07272772 · Colorectal | Phase 3 | Recrute | Turku University Hospital | 1 |
| Ligands FAP (FAPI)NCT07613099 · Athérosclérose et vaisseaux | Phase 3 | Recrute | National Heart, Lung, and Blood Institute (NHLBI) | 1 |
| Ligands FAP (FAPI)2024-516486-36-00 · Pancréas (adénocarcinome) | Phase 3 | Recrute | Stichting Amsterdam UMC | 1 |
| Ligands FAP (FAPI)2026-526942-29-00 · Maladies inflammatoires | Phase 3 | Pas encore ouvert | UZ Leuven | 1 |
| PLASTIC-3 · Ligands FAP (FAPI)NCT07018661 · Estomac / œsophage | Phase 3 | Recrute | Leiden University Medical Center | 1 |
| Ligands FAP (FAPI)2024-517931-29-00 · Maladies inflammatoires | Phase 3 | Recrute | Universitair Medisch Centrum Groningen | 1 |
| FAPIDO · Ligands FAP (FAPI)NCT06782412 · Pancréas (adénocarcinome) | Phase 3 | Recrute | KU Leuven | 1 |
| Ligands FAP (FAPI)2025-520731-17-02 · Autre | Phase 3 | Pas encore ouvert | Centre Hospitalier Regional Et Universitaire De Brest | 1 |
| Ligands FAP (FAPI)2024-517257-27-00 · Autre | Phase 3 | Recrute | Universitair Medisch Centrum Groningen | 1 |
| Ligands FAP (FAPI)NCT07702292 · Sein | Phase 2 | Recrute | Blue Earth Diagnostics | 2 |
| Ligands FAP (FAPI)NCT07432633 · Sein | Phase 2 | Recrute | Blue Earth Diagnostics | 1 |
| Ligands FAP (FAPI)NCT05518903 · Pancréas (adénocarcinome) | Phase 2 | Recrute | Mayo Clinic | 1 |
| BEFAST · Ligands FAP (FAPI)NCT07629609 · Pancréas (adénocarcinome) | Phase 2 | Recrute | Barbara Malene Fischer | 1 |
| FAPIPET · Ligands FAP (FAPI)NCT07705074 · Maladies inflammatoires | Phase 2 | Pas encore ouvert | Martin Huellner | 1 |
| Ligands FAP (FAPI)2024-518765-96-00 · Tumeurs solides (multi-indications) | Phase 2 | Recrute | Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico | 1 |
| FAPI-NICM · Ligands FAP (FAPI)NCT07878338 · Cardiopathie ischémique | Phase 2 | Recrute | Peking Union Medical College Hospital | 1 |
| Ligands FAP (FAPI)NCT06503146 · Phéochromocytome / paragangliome | Phase 2 | Recrute | National Cancer Institute (NCI) | 1 |
| FAPI-PM · Ligands FAP (FAPI)NCT06790082 · Tumeurs solides (multi-indications) | Phase 2 | Recrute | Aalborg University Hospital | 1 |
| Ligands FAP (FAPI)NCT07083011 · Insuffisance cardiaque et cardiomyopathies | Phase 2 | Recrute | Mayo Clinic | 1 |
| PHANTOM · Ligands FAP (FAPI)NCT06298916 · Pancréas (adénocarcinome) | Phase 2 | Recrute | Lantheus Medical Imaging | 1 |
| Ligands FAP (FAPI)NCT06335069 · Sein | Phase 2 | Recrute | Maastricht University Medical Center | 1 |
| Ligands FAP (FAPI)2024-511659-17-00 · Tumeurs solides (multi-indications) | Phase 2 | Recrute | Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l. | 1 |
| Ligands FAP (FAPI)2024-514504-13-00 · Maladies inflammatoires | Phase 2 | Recrute | MoonLake Immunotherapeutics AG | 1 |
| Ligands FAP (FAPI)NCT07523607 · Sein | Phase 2 | Pas encore ouvert | Odense University Hospital | 0 |
| Ligands FAP (FAPI)2023-503686-26-02 · Maladies inflammatoires | Phase 2 | Recrute | St Antonius Hospital | 1 |
| FAPDIG · Ligands FAP (FAPI)NCT07478523 · Pancréas (adénocarcinome) | Phase 2 | Recrute | University Hospital, Bordeaux | 1 |
| FAPICAM · Ligands FAP (FAPI)NCT07549841 · Amylose cardiaque | Phase 2 | Recrute | Nantes University Hospital | 1 |
| HEFITEP · Ligands FAP (FAPI)NCT06160271 · Psychiatrie et addictions | Phase 2 | Pas encore ouvert | Central Hospital, Nancy, France | 0 |
| Ligands FAP (FAPI)NCT07062523 · Maladies inflammatoires | Phase 2 | Recrute | Peking Union Medical College Hospital | 1 |
| FAPIHN · Ligands FAP (FAPI)NCT06794372 · ORL | Phase 2 | Recrute | John O. Prior | 1 |
| BEFAST · Ligands FAP (FAPI)NCT07215182 · Mélanome | Phase 2 | Recrute | Barbara Malene Fischer | 1 |
| Ligands FAP (FAPI)2025-524874-41-00 · Sarcome / os | Phase 2 | Pas encore ouvert | Rigshospitalet | 1 |
| Ligands FAP (FAPI)2024-511977-31-01 · Athérosclérose et vaisseaux | Phase 2 | Pas encore ouvert | Universitair Medisch Centrum Groningen | 1 |
| MI-CISDIR · Ligands FAP (FAPI)NCT06540872 · Sein | Phase 2 | Recrute | Universität Münster | 1 |
| INDIGO-FAPI · Ligands FAP (FAPI)NCT06659705 · Pancréas (adénocarcinome) | Phase 2 | Recrute | Institut Curie | 1 |
| Ligands FAP (FAPI)2025-524897-40-00 · Sein | Phase 2 | Pas encore ouvert | Hospices Civils De Lyon | 1 |
| SOFAPI · Ligands FAP (FAPI)NCT07357974 · Autre | Phase 2 | Pas encore ouvert | University Hospital, Brest | 1 |
| Ligands FAP (FAPI)2025-524434-25-00 · Estomac / œsophage | Phase 2 | Pas encore ouvert | Centre Hospitalier Universitaire De Bordeaux | 1 |
| Ligands FAP (FAPI)NCT07285993 · Sein | Phase 2 | Pas encore ouvert | Randy Yeh | 1 |
| Ligands FAP (FAPI)2025-521163-12-01 · Thyroïde | Phase 2 | Pas encore ouvert | Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) | 1 |
| Ligands FAP (FAPI)NCT07464132 · Insuffisance cardiaque et cardiomyopathies | Phase 2 | Recrute | Peking Union Medical College Hospital | 1 |
| Ligands FAP (FAPI)2025-523032-39-00 · Poumon à petites cellules | Phase 2 | Pas encore ouvert | Academisch Ziekenhuis Maastricht | 1 |
| Ligands FAP (FAPI)NCT05172310 · Pancréas (adénocarcinome) | Phase 1 | Recrute | Karolinska University Hospital | 1 |
| Ligands FAP (FAPI)NCT04499365 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | First Affiliated Hospital of Fujian Medical University | 1 |
| Ligands FAP (FAPI)NCT06740240 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | First Affiliated Hospital of Fujian Medical University | 1 |
| Ligands FAP (FAPI)2023-506594-35-00 · Colorectal | Phase 1 | Recrute | Amsterdam UMC | 1 |
| Ligands FAP (FAPI)NCT04621435 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | Thomas Hope | 1 |
| Ligands FAP (FAPI)NCT07144085 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | Yi Tian | 1 |
| Ligands FAP (FAPI)NCT05121779 · Maladies inflammatoires | Phase 1 | Recrute | Peking Union Medical College Hospital | 1 |
| Ligands FAP (FAPI)2024-518838-82-00 · Maladies inflammatoires | Phase 1 | Recrute | Universitair Medisch Centrum Groningen | 1 |
| Ligands FAP (FAPI)NCT06413355 · Maladies inflammatoires | Phase 1 | Recrute | Abramson Cancer Center at Penn Medicine | 1 |
| FAPI-PETCD · Ligands FAP (FAPI)NCT07273188 · Maladies inflammatoires | Phase 1 | Recrute | Mayo Clinic | 1 |
| Ligands FAP (FAPI)NCT07457541 · Sein | Phase 1 | Actif, ne recrute plus | Tomsk National Research Medical Center of the Russian Academy of Sciences | 1 |
| Ligands FAP (FAPI)NCT06688305 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | First Affiliated Hospital of Fujian Medical University | 1 |
| Ligands FAP (FAPI)2023-505317-25-00 · Maladies inflammatoires | Phase 1 | Recrute | Amsterdam UMC | 1 |
| FAPI PET Prost · Ligands FAP (FAPI)NCT04457232 · Prostate – autre | Phase 1 | Actif, ne recrute plus | Jonsson Comprehensive Cancer Center | 1 |
| FAPI ILD · Ligands FAP (FAPI)NCT05365802 · Maladies inflammatoires | Phase 1 | Actif, ne recrute plus | University of California, Los Angeles | 1 |
| Ligands FAP (FAPI)NCT07118176 · Prostate – autre | Phase 1 | Actif, ne recrute plus | Jonsson Comprehensive Cancer Center | 1 |
| Ligands FAP (FAPI)NCT07132645 · TNE et carcinomes neuroendocrines (autres) | Phase 1 | Recrute | University of Michigan Rogel Cancer Center | 1 |
| Ligands FAP (FAPI)NCT07817563 · Poumon non à petites cellules | Phase 1 | Pas encore ouvert | Mayo Clinic | 1 |
| FAPI PET RDRC · Ligands FAP (FAPI)NCT04459273 · TNE et carcinomes neuroendocrines (autres) | Phase 1 | Actif, ne recrute plus | Jonsson Comprehensive Cancer Center | 1 |
| Ligands FAP (FAPI)2023-503985-21-00 · Poumon à petites cellules | Phase 1 | Recrute | Meander Medisch Centrum | 1 |
| Ligands FAP (FAPI)NCT04457258 · Sarcome / os | Phase 1 | Actif, ne recrute plus | Jonsson Comprehensive Cancer Center | 1 |
| Ligands FAP (FAPI)NCT06734572 · Tumeurs solides (multi-indications) | Phase 1 | Recrute | First Affiliated Hospital of Fujian Medical University | 1 |
| Ligands FAP (FAPI)NCT07830771 · Infections bactériennes | Phase 1 | Recrute | University of Pennsylvania | 1 |
| CUPCAKE · Ligands FAP (FAPI)NCT06225505 · Sein | Sans phase | Recrute | Institut Curie | 1 |
| Ligands FAP (FAPI)NCT05034146 · Tumeurs solides (multi-indications) | Sans phase | Recrute | Zhongnan Hospital | 1 |
| Ligands FAP (FAPI)NCT06421142 · Vessie / urothélial | Sans phase | Recrute | First Affiliated Hospital of Fujian Medical University | 1 |
| Ligands FAP (FAPI)NCT04416165 · Tumeurs solides (multi-indications) | Sans phase | Recrute | The First Affiliated Hospital of Xiamen University | 1 |
| Ligands FAP (FAPI)NCT07753499 · Thyroïde | Sans phase | Recrute | The First Affiliated Hospital of Xiamen University | 1 |
| PARADISE · Ligands FAP (FAPI)NCT06275477 · Maladies inflammatoires | Sans phase | Recrute | University Hospital, Brest | 1 |
| Ligands FAP (FAPI)NCT07180433 · Sein | Sans phase | Pas encore ouvert | St. Olavs Hospital | 0 |
| EM-FAPI · Ligands FAP (FAPI)NCT07876648 · Maladies inflammatoires | Sans phase | Recrute | Universitaire Ziekenhuizen KU Leuven | 1 |
| Ligands FAP (FAPI)NCT06232122 · Gynécologique | Sans phase | Recrute | Chang Gung Memorial Hospital | 1 |
| Ligands FAP (FAPI)NCT06791226 · Tumeurs solides (multi-indications) | Sans phase | Recrute | Peking University Third Hospital | 1 |
| Ligands FAP (FAPI)NCT05442151 · Tumeurs solides (multi-indications) | Sans phase | Recrute | Tadashi Watabe | 1 |
| Ligands FAP (FAPI)NCT06653452 · Colorectal | Sans phase | Recrute | Peking Union Medical College Hospital | 1 |
| Ga-68-FAPI-46 · Ligands FAP (FAPI)NCT06769828 · Colorectal | Sans phase | Recrute | Koo Foundation Sun Yat-Sen Cancer Center | 1 |
| PKUCH-R12 · Ligands FAP (FAPI)NCT07552207 · Colorectal | Sans phase | Pas encore ouvert | Peking University Cancer Hospital & Institute | 0 |
| Ligands FAP (FAPI)NCT06911021 · Pancréas (adénocarcinome) | Sans phase | Pas encore ouvert | Centre Hospitalier Universitaire Vaudois | 1 |
| FAPeCa · Ligands FAP (FAPI)NCT06061874 · Tumeurs solides (multi-indications) | Sans phase | Recrute | Jules Bordet Institute | 1 |
| INTERACT-FAPI · Ligands FAP (FAPI)NCT06957782 · Autre | Sans phase | Pas encore ouvert | Erasmus Medical Center | 0 |
| Ligands FAP (FAPI)NCT07114211 · Autre | Sans phase | Pas encore ouvert | Xijing Hospital | 0 |
| Ligands FAP (FAPI)NCT05140746 · Estomac / œsophage | Sans phase | Recrute | Ruijin Hospital | 1 |
| FAP-IT · Ligands FAP (FAPI)NCT06349512 · Sein | Sans phase | Recrute | Institut Curie | 1 |
| FAPI-PET · Ligands FAP (FAPI)NCT06790264 · Sein | Sans phase | Recrute | European Institute of Oncology | 1 |
| FAPI for CUP · Ligands FAP (FAPI)NCT06644716 · Tumeurs solides (multi-indications) | Sans phase | Recrute | Erasmus Medical Center | 1 |
| FoCus · Ligands FAP (FAPI)NCT06191120 · Colorectal | Sans phase | Recrute | UMC Utrecht | 1 |
| Ligands FAP (FAPI)NCT07104058 · Maladies inflammatoires | Sans phase | Recrute | Luo Yaping | 1 |
| Ligands FAP (FAPI)NCT07423013 · Thyroïde | Sans phase | Recrute | Peking University Third Hospital | 1 |
| FAPI-ARVC · Ligands FAP (FAPI)NCT07563660 · Insuffisance cardiaque et cardiomyopathies | Sans phase | Recrute | Istanbul University - Cerrahpasa | 1 |
| GALILEE · Ligands FAP (FAPI)NCT05931302 · Sein | Sans phase | Actif, ne recrute plus | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer | 1 |
| FAST HOC · Ligands FAP (FAPI)NCT05956093 · Gynécologique | Sans phase | Actif, ne recrute plus | University Health Network, Toronto | 1 |
| Ligands FAP (FAPI)NCT06684028 · Tumeurs solides (multi-indications) | Sans phase | Recrute | Affiliated Hospital of Jiangnan University | 1 |
| Ligands FAP (FAPI)NCT07138729 · Maladies inflammatoires | Sans phase | Recrute | Luo Yaping | 1 |
FAP. Theranostic Atlas, LaRadiopharmacie.fr. Données du 26 octobre 2026. https://theranosticatlas.com/fr/target/fap/ (consulté le [date]).
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