Thyroid (NIS)

Ongoing clinical trials and approved products targeting Thyroid (NIS), in radioligand therapy and PET/SPECT imaging. Data as of 26 October 2026.

0ongoing therapy trials

3ongoing imaging trials

0approved products

Target note

Full name: Sodium-iodide symporter (NIS)
Nature: Membrane iodide transporter of thyrocytes.
Normal expression: Thyroid, salivary glands, stomach.
Value: Functional imaging of the thyroid and of metastases from differentiated cancers; reporter gene.
Approaches: [18F]tetrafluoroborate, ¹²⁴I, ¹²³I, [99mTc]pertechnetate.
Indications explored: Hyperthyroidism, differentiated thyroid cancers.
Points of caution: Iodine saturation (contrast media, amiodarone).

Ongoing imaging trials · 3Open in the radar →

Trial	Phase	Status	Sponsor	Countries
[18F]tetrafluoroborate2024-516025-30-00 · Thyroid	Phase 2	Recruiting	Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)	1
NISDETECT · [18F]tetrafluoroborateNCT07436455 · Thyroid	No phase	Recruiting	Ankara University	1
[18F]tetrafluoroborateNCT03196518 · Thyroid	No phase	Active, not recruiting	Memorial Sloan Kettering Cancer Center	1

Cite this page

Thyroid (NIS). Theranostic Atlas, LaRadiopharmacie.fr. Data as of 26 October 2026. https://theranosticatlas.com/target/thyroid-nis/ (accessed [date]).

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