Tau

Ongoing clinical trials and approved products targeting Tau, in radioligand therapy and PET/SPECT imaging. Data as of 26 October 2026.

0ongoing therapy trials
26ongoing imaging trials
2approved products

Target note

Full name
Aggregated tau protein (neurofibrillary tangles)
Nature
Ligands of the hyperphosphorylated tau aggregates of Alzheimer's disease, with variable affinity for non-Alzheimer tauopathies.
Normal expression
Non-specific uptake in the choroid plexus, basal ganglia and meninges depending on the tracer.
Value
Tau burden and distribution correlate better with symptoms than amyloid; staging (Braak) and prognosis.
Approaches
[18F]flortaucipir (Tauvid), [18F]florquinitau / MK-6240 (Tauklarify), [18F]PI-2620, [18F]RO948, [18F]APN-1607.
Indications explored
Alzheimer's disease; research in primary tauopathies (progressive supranuclear palsy, corticobasal degeneration).
Points of caution
Off-target uptake specific to each tracer; limited performance in non-Alzheimer tauopathies.

Approved products

Tauvid[18F]flortaucipirLillymarketedUS EU FR
Tauklarify[18F]florquinitau (MK-6240)Lantheusapproved (2026)US

Ongoing imaging trials · 26Open in the radar →

TrialPhaseStatusSponsorCountries
Tau protein tracersNCT07115238 · Alzheimer's disease and cognitive disordersPhase 3RecruitingSinotau Pharmaceutical Group1
Tau protein tracersNCT05641688 · Alzheimer's disease and cognitive disordersPhase 3RecruitingLantheus Biosciences Ltd.1
Tau protein tracersNCT07422857 · Alzheimer's disease and cognitive disordersPhase 3RecruitingJYAMS PET Research & Development Limited1
Tau protein tracers2024-517074-17-00 · Alzheimer's disease and cognitive disordersPhase 3RecruitingCliniques Universitaires Saint-Luc1
Tau protein tracersNCT03143374 · Other neurodegenerative diseasesPhase 3RecruitingUniversity of Pennsylvania1
Tau protein tracers2023-505430-10-00 · Alzheimer's disease and cognitive disordersPhase 3RecruitingAmsterdam UMC1
Tau protein tracersNCT05456503 · Alzheimer's disease and cognitive disordersPhase 3RecruitingUniversity of Pennsylvania1
Tau protein tracersNCT07752784 · Alzheimer's disease and cognitive disordersPhase 3RecruitingJYAMS PET Research & Development Limited1
Tau protein tracers2024-519995-20-00 · Alzheimer's disease and cognitive disordersPhase 3Not yet recruitingInstitut National De La Sante Et De La Recherche Medicale1
Quanti-TAU-PET · Tau protein tracersNCT07105384 · Parkinson's disease and parkinsonian syndromesPhase 2Active, not recruitingFundacion Clinic per a la Recerca Biomédica1
NOMEM-Tau · Tau protein tracersNCT03389100 · Diabetes and obesityPhase 2By invitationColumbia University1
Tau protein tracersNCT06723015 · Alzheimer's disease and cognitive disordersPhase 2By invitationMayo Clinic1
Tau protein tracersNCT07020026 · Parkinson's disease and parkinsonian syndromesPhase 2RecruitingMichael J. Fox Foundation for Parkinson's Research1
Tau protein tracers2024-515574-27-00 · Alzheimer's disease and cognitive disordersPhase 2RecruitingFundacio Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau1
Tau protein tracers2024-517048-67-00 · Stroke and traumaPhase 2RecruitingRegion Skane1
Tau protein tracers2024-517634-17-01 · Alzheimer's disease and cognitive disordersPhase 2RecruitingAmsterdam UMC Stichting1
Tau protein tracers2025-522826-11-00 · Alzheimer's disease and cognitive disordersPhase 2RecruitingZRO Imaging AB1
Tau protein tracers2023-503538-37-00 · Parkinson's disease and parkinsonian syndromesPhase 2RecruitingUniversity Clinic Of Navarra1
Tau protein tracersNCT06297590 · Alzheimer's disease and cognitive disordersPhase 1RecruitingEli Lilly and Company3
Tau protein tracersNCT05464368 · Alzheimer's disease and cognitive disordersPhase 1Active, not recruitingWashington University School of Medicine1
AV1451 ADC · Tau protein tracersNCT03809351 · Alzheimer's disease and cognitive disordersPhase 1RecruitingUniversity of Alabama at Birmingham1
Tau protein tracersNCT07580703 · Alzheimer's disease and cognitive disordersPhase 1RecruitingEli Radiopharma1
Tau protein tracersNCT02605785 · Parkinson's disease and parkinsonian syndromesNo phaseRecruitingMayo Clinic1
Add-Tau · Tau protein tracersNCT02958670 · Alzheimer's disease and cognitive disordersNo phaseActive, not recruitingUniversity of Zurich1
Tau protein tracersNCT04482660 · Alzheimer's disease and cognitive disordersNo phaseBy invitationBarcelonabeta Brain Research Center, Pasqual Maragall Foundation1
ROADAD · Tau protein tracersNCT06731842 · Alzheimer's disease and cognitive disordersNo phaseBy invitationKarolinska Institutet1

Cite this page

Tau. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 26 October 2026. https://theranosticatlas.com/target/tau/ (accessed [date]).

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