T-cell activation

Ongoing clinical trials and approved products targeting T-cell activation, in radioligand therapy and PET/SPECT imaging. Data as of 26 October 2026.

0ongoing therapy trials
11ongoing imaging trials
0approved products

Target note

Full name
Activated T cells (deoxyguanosine kinase)
Nature
F-AraG is phosphorylated by mitochondrial deoxyguanosine kinase, highly active in activated T cells.
Normal expression
Kidneys, liver, heart, muscles.
Value
Visualising the anti-tumor immune response or transplant rejection.
Approaches
[18F]F-AraG.
Indications explored
Cancer immunotherapy, transplantation, autoimmune diseases (research).
Points of caution
Research stage.

Ongoing imaging trials · 11Open in the radar →

TrialPhaseStatusSponsorCountries
[18F]F-AraGNCT04815096 · Bacterial infectionsPhase 2RecruitingCellSight Technologies, Inc.1
[18F]F-AraGNCT06107374 · Small-cell lung cancerPhase 2RecruitingCellSight Technologies, Inc.1
[18F]F-AraGNCT03684655 · Bacterial infectionsPhase 2RecruitingCellSight Technologies, Inc.1
[18F]F-AraGNCT07611357 · Alzheimer's disease and cognitive disordersPhase 2Not yet recruitingCellSight Technologies, Inc.0
[18F]F-AraGNCT06084806 · Small-cell lung cancerPhase 2RecruitingCellSight Technologies, Inc.1
[18F]F-AraGNCT00004847 · Pheochromocytoma / paragangliomaPhase 1RecruitingEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)1
[18F]F-AraGNCT07076862 · Bacterial infectionsPhase 1RecruitingUniversity of California, Davis1
[18F]F-AraGNCT07168785 · Head and neckPhase 1Not yet recruitingIndiana University1
iRelate · [18F]F-AraGNCT06457789 · Small-cell lung cancerNo phaseRecruitingAmsterdam UMC, location VUmc1
SHARP · [18F]F-AraGNCT05701176 · Small-cell lung cancerNo phaseRecruitingAmsterdam UMC, location VUmc1
ATTAIN · [18F]F-AraGNCT05157659 · Small-cell lung cancerNo phaseActive, not recruitingAmsterdam UMC, location VUmc1

Cite this page

T-cell activation. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 26 October 2026. https://theranosticatlas.com/target/t-cell-activation/ (accessed [date]).

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