NET (MIBG)

Ongoing clinical trials and approved products targeting NET (MIBG), in radioligand therapy and PET/SPECT imaging. Data as of 26 October 2026.

7ongoing therapy trials

0ongoing imaging trials

1approved products

Target note

Full name: Norepinephrine transporter (NET, SLC6A2 gene) — targeted by MIBG
Nature: Membrane transporter for catecholamine reuptake; MIBG, a guanethidine analogue, enters through it and is then stored in neurosecretory granules (VMAT).
Normal expression: Sympathetic nerve terminals (heart, salivary glands), adrenal medulla, liver.
Disease expression: Neuroblastoma, pheochromocytoma and paraganglioma, some carcinoid tumors, medullary thyroid cancer.
Value: A functional target seen on ¹²³I-MIBG scintigraphy, used for therapy since the 1980s.
Approaches: ¹³¹I-MIBG (standard or high specific activity), ²¹¹At-MABG (α analogue).
Indications explored: High-risk or refractory neuroblastoma (including in combination), metastatic pheochromocytomas and paragangliomas.
Points of caution: Many drug interactions block uptake (labetalol, tricyclic antidepressants, some sympathomimetics); thyroid blocking with iodide; myelotoxicity; radiation protection of relatives with ¹³¹I.

Azedra[131I]Iobenguane (high specific activity)	Progenics / Lantheus	discontinued
MIBG [131I] for therapy[131I]Iobenguane	GE Healthcare (AMM nationale danoise)	marketed (national authorisations)	EU FR JP

Trial	Phase	Status	Sponsor	Countries
[131I]MIBGNCT03126916 · Neuroblastoma	Phase 3	Recruiting	Children's Oncology Group	3
[131I]MIBGNCT07261241 · Neuroblastoma	Phase 2	Not yet recruiting	New Approaches to Neuroblastoma Therapy Consortium	1
MIBG · [131I]MIBGNCT02378428 · Solid tumors (multiple indications)	Phase 2	Active, not recruiting	Nationwide Children's Hospital	1
[131I]MIBGNCT00107289 · Neuroblastoma	Phase 2	Recruiting	Memorial Sloan Kettering Cancer Center	1
MiniVan · [131I]MIBGNCT02914405 · Neuroblastoma	Phase 1	Active, not recruiting	University Hospital Southampton NHS Foundation Trust	2
1 MBq/k of 211At-MABG FractionatedNCT07661420 · Pheochromocytoma / paraganglioma	Phase 1	Not yet recruiting	University of Pennsylvania	1
[211At]MABGNCT07767630 · Neuroblastoma	Phase 1	Recruiting	Sichuan University	1

NET (MIBG). Theranostic Atlas, LaRadiopharmacie.fr. Data as of 26 October 2026. https://theranosticatlas.com/target/net-mibg/ (accessed [date]).

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