Catecholamine synthesis (FDOPA)

Ongoing clinical trials and approved products targeting Catecholamine synthesis (FDOPA), in radioligand therapy and PET/SPECT imaging. Data as of 26 October 2026.

0ongoing therapy trials

13ongoing imaging trials

1approved products

Target note

Full name: Catecholamine synthesis pathway (LAT1, aromatic amino acid decarboxylase)
Nature: FDOPA is taken up by the LAT1 transporter, then decarboxylated to fluorodopamine and stored in vesicles.
Normal expression: Striatum, pancreas, urinary tract.
Value: Dual use: presynaptic dopaminergic integrity in neurology, and imaging of neuroendocrine tumors in oncology.
Approaches: [18F]FDOPA, often after carbidopa premedication in oncology.
Indications explored: Parkinsonian syndromes; pheochromocytomas and paragangliomas, medullary thyroid cancer, small bowel NETs, gliomas; focal congenital hyperinsulinism.
Points of caution: Physiological pancreatic uptake hampers analysis of the pancreas; influence of dopaminergic treatments.

Approved products

FDOPA (Feinstein, IASOdopa, Dopacis…)[18F]fluorodopa

Multiples

marketed

US EU FR

Ongoing imaging trials · 13Open in the radar →

Trial	Phase	Status	Sponsor	Countries
[18F]FDOPANCT04706910 · Parkinson's disease and parkinsonian syndromes	Phase 3	Recruiting	University of Alberta	1
KING · [18F]FDOPANCT05512403 · Brain (glioma, medulloblastoma…)	Phase 3	Recruiting	Central Hospital, Nancy, France	1
ADACHOL · [18F]FDOPANCT03998852 · Other	Phase 3	Recruiting	University Hospital, Bordeaux	1
DOPA PET · [18F]FDOPANCT04205604 · Hyperinsulinism and insulinoma	Phase 2	Recruiting	Miguel Pampaloni	1
FdopaPD2 · [18F]FDOPANCT04459052 · Parkinson's disease and parkinsonian syndromes	Phase 2	Active, not recruiting	Thomas Jefferson University	1
[18F]FDOPANCT07542158 · Parkinson's disease and parkinsonian syndromes	Phase 2	By invitation	Akiva Mintz	1
18FDOPA HI · [18F]FDOPANCT05088798 · Hyperinsulinism and insulinoma	Phase 2	Recruiting	Washington University School of Medicine	1
[18F]FDOPANCT05255159 · NETs and neuroendocrine carcinomas (other)	Phase 2	Active, not recruiting	University of Alberta	1
[18F]FDOPANCT06667726 · Brain (glioma, medulloblastoma…)	Phase 2	Recruiting	Mayo Clinic	1
[18F]FDOPANCT02021604 · Hyperinsulinism and insulinoma	Phase 1	Recruiting	Cook Children's Health Care System	1
[18F]FDOPANCT04246437 · Alzheimer's disease and cognitive disorders	Phase 1	Recruiting	Daniel Claassen	1
[18F]FDOPANCT03541720 · Neuroblastoma	Phase 1	Active, not recruiting	St. Jude Children's Research Hospital	1
EARLYBRAINPET · [18F]FDOPANCT07274397 · Brain (glioma, medulloblastoma…)	No phase	Recruiting	Beta Emitting Accurate Monitored Systems	1

Cite this page

Catecholamine synthesis (FDOPA). Theranostic Atlas, LaRadiopharmacie.fr. Data as of 26 October 2026. https://theranosticatlas.com/target/catecholamine-synthesis-fdopa/ (accessed [date]).

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