Cardiac amyloidosis

Ongoing clinical trials and approved products targeting Cardiac amyloidosis, in radioligand therapy and PET/SPECT imaging. Data as of 26 October 2026.

0ongoing therapy trials
12ongoing imaging trials
1approved products

Target note

Full name
Myocardial amyloid deposits
Nature
Technetium-labeled bisphosphonates bind to the microcalcifications of transthyretin deposits; PET amyloid tracers bind to the fibrils.
Normal expression
Bone (skeleton).
Value
Non-invasive diagnosis of transthyretin amyloidosis (without biopsy if electrophoresis shows no AL amyloidosis); PET is being explored for AL amyloidosis and follow-up.
Approaches
SPECT: [99mTc]DPD, HMDP, pyrophosphate; PET: [18F]florbetapir, florbetaben, [11C]PiB, [124I]evuzamitide.
Indications explored
Transthyretin and light-chain cardiac amyloidosis.
Points of caution
Always rule out AL amyloidosis (electrophoresis, light chains); residual blood-pool activity to be distinguished (SPECT recommended).

Approved products

Bisphosphonates [99mTc] (DPD, HMDP, PYP)[99mTc]oxidronate, DPD, pyrophosphateMultiplesmarketed (historical indications)US EU FR JP

Ongoing imaging trials · 12Open in the radar →

TrialPhaseStatusSponsorCountries
Amyloid tracers2024-517942-33-03 · Cardiac amyloidosisPhase 3RecruitingFondazione Toscana Gabriele Monasterio1
Amyloid tracersNCT07560306 · Cardiac amyloidosisPhase 3RecruitingBrigham and Women's Hospital1
Amyloid tracersNCT05758493 · Cardiac amyloidosisPhase 2RecruitingOregon Health and Science University1
Abeta-MTRALCA · Amyloid tracersNCT07829705 · Cardiac amyloidosisPhase 2RecruitingPeking Union Medical College Hospital1
Amyloid tracersNCT06907849 · Cardiac amyloidosisPhase 2By invitationUniversity of Tennessee Graduate School of Medicine1
FIDTCA · [99mTc]PYP / DPD / HMDPNCT07835880 · Cardiac amyloidosisPhase 2Not yet recruitingPeking Union Medical College Hospital1
Amyloid tracersNCT05951816 · Cardiac amyloidosisPhase 1RecruitingUniversity of Tennessee Graduate School of Medicine1
FSA-CA · Amyloid tracersNCT07771621 · Cardiac amyloidosisPhase 1By invitationWashington University School of Medicine1
MICA · Amyloid tracersNCT02641145 · Cardiac amyloidosisNo phaseRecruitingBrigham and Women's Hospital1
TTRinHFpEF · [99mTc]PYP / DPD / HMDPNCT05577819 · Cardiac amyloidosisNo phaseRecruitingMassachusetts General Hospital1
[99mTc]PYP / DPD / HMDPNCT07580872 · Cardiac amyloidosisNo phaseNot yet recruitingLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's0
REMOD-TTR · Amyloid tracersNCT04535349 · Cardiac amyloidosisNo phaseRecruitingUniversity Hospital, Caen1

Cite this page

Cardiac amyloidosis. Theranostic Atlas, LaRadiopharmacie.fr. Data as of 26 October 2026. https://theranosticatlas.com/target/cardiac-amyloidosis/ (accessed [date]).

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